| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1841 |
| Uniprot No | Q6NSI8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-718aa |
| 活性数据 | MSRGYSENNN FLNNNNQMVL DMILYPLIGI PQTINWETIA RLVPGLTPKE CAKRFDELKS SGSSPVDNQY NSLMAAGESP VETLATYIKS SLLDIHGEFQ ETPVGHDAVS KTGRHSIAST RNCSSESENC TTHNGGEMTE ESEGPNMVIH VCDEAKNLKE DFTCPRDLLI SEMKYFAEYL SMDAQRWEEV DISVHCDVHI FNWLIKYIKR NTKENKDCEM PTLEPGNVIS ILISSEFLKM DSLVEQCIQY CHKNMNAIVA TPCNMNCINA NLLTRIADLF SHNEVDDLKD KKDKFKSKLF CKKIERLFDP EYLNPDSRSN AATLYRCCLC KKLLTKETER RIPCIPGKIN VDRRGNIVYI HIRDKTWDVH EYLNSLFEEL KSWRDVYWRL WGTINWLTCS RCYQAFLCIE FSHCQYHSET VVYPTAASSL NTVGTGIYPC CNQKVLRFDP TQLTKGCKVR DHMVTLRDQG EGGDLPSCPT ARMLDDLHKY RDVIVVPFSK DTVSDVGVGL CDEKGIECDV LLEPNTPWGP KTGELNAFLS LKNWTLQLKQ QSLFSEEEEY TTGSEVTEDE VGDEEEVSKK QRKKEKPKKF TRQPKKQVSS PCAQRKEKAL EKSASRDVSP FVMSMQKNKW DATRSLRFNQ DAQREDDQRR MTEITGHLIK MRLGDLDRVK SKEAKEFAGG IYSRLEAQIK ASVPVSARQS SSEKNTRSKS RFGQGRPA |
| 分子量 | 82 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1841蛋白的3篇模拟参考文献及其摘要概括(注：文献为假设性示例，实际研究需查阅真实数据库)：
1. **《KIAA1841的结构解析及其在细胞骨架动态调控中的作用》**
- 作者：Zhang L., et al.
- 摘要：本研究通过X射线晶体学解析了KIAA1841蛋白的N端结构域，发现其具有典型的螺旋-环-螺旋构象，并证实其通过与微管相关蛋白相互作用调节细胞骨架重组和细胞迁移。
2. **《KIAA1841在有丝分裂中的功能缺失导致染色体不稳定》**
- 作者：Wang Y., et al.
- 摘要：通过RNA干扰技术敲低KIAA1841.发现其缺失导致HeLa细胞有丝分裂中期染色体排列紊乱，提示该蛋白在纺锤体组装和染色体分离中起关键作用。
3. **《KIAA1841在胶质母细胞瘤中的高表达及其临床意义》**
- 作者：Kim S., et al.
- 摘要：分析胶质母细胞瘤样本显示，KIAA1841在肿瘤组织中显著高表达，且与患者生存期缩短相关，可能作为潜在预后标志物及治疗靶点。
4. **《KIAA1841与DNA修复通路蛋白的相互作用网络研究》**
- 作者：Müller F., et al.
- 摘要：基于质谱分析发现KIAA1841与BRCA1和Rad51存在物理相互作用，推测其参与DNA双链断裂修复，可能影响基因组稳定性。
建议通过PubMed、Google Scholar等平台检索真实文献，使用关键词“KIAA1841”、“重组蛋白”或“C7orf43”(已知别名)获取准确信息。
Recombinant human KIAA1841 protein, also known as C19orf57 or Disco-interacting protein 2 homolog B (DIP2B), is a less-characterized protein encoded by the KIAA1841 gene located on chromosome 19. The protein contains conserved domains, including an N-terminal CoA-binding motif, suggesting potential roles in enzymatic or metabolic processes. Although its precise biological function remains unclear, studies indicate involvement in neural development, as DIP2B homologs in model organisms regulate axon guidance and synaptic connectivity. It may also modulate transcriptional regulation or epigenetic pathways through interactions with chromatin-associated proteins, though mechanistic insights are limited.
KIAA1841 has been implicated in neurodevelopmental disorders and cancers. For instance, its altered expression is observed in gliomas and neuroblastomas, though causal links require validation. Recombinant forms of this protein are typically produced in bacterial or mammalian expression systems for in vitro studies, enabling investigations into its biochemical properties, interactomes, or subcellular localization. Current research focuses on elucidating its structural motifs, post-translational modifications, and functional crosstalk with signaling pathways like Wnt or Notch. Despite emerging associations with disease, KIAA1841 remains understudied, highlighting the need for further exploration of its physiological and pathological relevance.
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