| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1285 |
| Uniprot No | Q9ULD5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-518aa |
| 活性数据 | MRGNYESLVSMDYAISKPDLMSQMERGERPTMQEQEDSEEGETPTDPSAAHDGIVIKIEVQTNDEGSESLETPEPLMGQVEEHGFQDSELGDPCGEQPDLDMQEPENTLEESTEGSSEFSELKQMLVQQRNCTEGIVIKTEEQDEEEEEEEEDELPQHLQSLGQLSGRYEASMYQTPLPGEMSPEGEESPPPLQLGNPTVKRLAPSVHGERHLSENRGASSQQQRNRRGERPFTCMECGKSFRLKINLIIHQRNHIKEGPYECAECEISFRHKQQLTLHQRIHRVRGGCVSPERGPTFNPKHALKPRPKSPSSGSGGGGPKPYKCPECDSSFSHKSSLTKHQITHTGERPYTCPECKKSFRLHISLVIHQRVHAGKHEVSFICSLCGKSFSRPSHLLRHQRTHTGERPFKCPECEKSFSEKSKLTNHCRVHSRERPHACPECGKSFIRKHHLLEHRRIHTGERPYHCAECGKRFTQKHHLLEHQRAHTGERPYPCTHCAKCFRYKQSLKYHLRTHTGE |
| 分子量 | 85.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1285蛋白的3篇文献示例(经合理虚构，供参考格式)：
1. **文献名称**：*"Functional characterization of recombinant human KIAA1285 in Wnt signaling regulation"*
**作者**：Zhang L et al.
**摘要**：研究成功表达并纯化了重组人KIAA1285蛋白，发现其通过结合β-catenin抑制Wnt信号通路，提示其可能参与肿瘤发生的调控。
2. **文献名称**：*"Structural analysis and substrate specificity of KIAA1285 as a novel deubiquitinase"*
**作者**：Kimura T et al.
**摘要**：通过重组蛋白技术解析KIAA1285的晶体结构，并证明其具有去泛素化酶活性，可能参与蛋白质稳态调控。
3. **文献名称**：*"KIAA1285 recombinant protein promotes neuronal differentiation in vitro"*
**作者**：Chen X et al.
**摘要**：实验表明重组人KIAA1285能激活MAPK通路，促进神经干细胞分化，为神经退行性疾病研究提供新靶点。
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**注**：实际文献可能较少或名称不同，建议结合基因别名(如FAM206A)在PubMed/Google Scholar检索。部分真实研究可能隐含在组学数据分析中，具体功能仍需实验验证。
Recombinant human KIAA1285 protein is a genetically engineered form of the protein encoded by the KIAA1285 gene, also known as LUZP2 (leucine zipper protein 2). This gene is located on chromosome 11q14.1 and encodes a protein containing conserved structural domains, including leucine-rich repeats and a coiled-coil motif, which are commonly associated with protein-protein interactions and intracellular signaling. KIAA1285 was initially identified through large-scale sequencing projects focused on uncharacterized human genes, and its biological functions remain under investigation. Preliminary studies suggest potential roles in cytoskeletal organization, cellular adhesion, and neural development, though mechanistic details are sparse.
Interest in recombinant KIAA1285 stems from its overexpression observed in certain cancers, such as hepatocellular carcinoma and glioblastoma, where it may influence tumor invasiveness and metastasis. Additionally, it has been implicated in developmental disorders, including rare congenital anomalies linked to 11q14.1 deletions. Recombinant forms of KIAA1285 are typically produced in bacterial or mammalian expression systems to facilitate functional studies, antibody development, and interaction partner screenings. Despite progress, the protein's precise molecular pathways and therapeutic relevance remain poorly characterized, underscoring the need for further research to elucidate its physiological and pathological contributions.
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