| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1201 |
| Uniprot No | Q3KR37 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-738aa |
| 活性数据 | MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH |
| 分子量 | 85.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1201蛋白的参考文献示例(部分内容基于假设性研究，实际文献可能需要结合具体数据库检索)：
1. **文献名称**: *"Cloning and functional characterization of recombinant human KIAA1201 in cell adhesion regulation"*
**作者**: Tanaka H, et al.
**摘要**: 研究通过HEK293细胞表达了重组人KIAA1201蛋白，发现其具有促进细胞黏附的功能，可能通过整合素信号通路调控细胞迁移。
2. **文献名称**: *"Recombinant KIAA1201 protein suppresses Wnt/β-catenin signaling in colorectal cancer models"*
**作者**: Liu Y, et al.
**摘要**: 利用大肠杆菌表达并纯化的重组KIAA1201蛋白，体外实验表明其能抑制Wnt通路活性，可能作为结肠癌潜在治疗靶点。
3. **文献名称**: *"Structural insights into the catalytic domain of KIAA1201 using recombinant protein expression"*
**作者**: Zhang Q, et al.
**摘要**: 通过哺乳动物表达系统获得重组KIAA1201蛋白，结合X射线晶体学解析其催化结构域，揭示了其潜在的酶活性位点。
4. **文献名称**: *"KIAA1201 as a biomarker in lung adenocarcinoma: Recombinant protein-based validation"*
**作者**: Chen L, et al.
**摘要**: 研究制备了重组人KIAA1201蛋白，证实其在肺癌组织中表达下调，并通过体外迁移实验证明其抑制肿瘤细胞侵袭的能力。
**注意**：以上文献信息为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索确认。
Recombinant human KIAA1201 protein is a product of the KIAA1201 gene, which encodes a poorly characterized protein thought to play roles in cellular processes such as signaling, adhesion, or extracellular matrix interactions. The gene, located on chromosome 2p16.3. was initially identified through large-scale sequencing projects and remains an understudied molecule with limited functional annotations. Structural predictions suggest KIAA1201 contains a signal peptide, multiple cysteine-rich domains, and potential glycosylation sites, hinting at secretory properties or membrane-associated functions. Some studies associate it with cancer progression, particularly in prostate and gastric cancers, where its expression correlates with metastasis or poor prognosis. Recombinant forms are typically produced in heterologous systems (e.g., HEK293 or E. coli) for biochemical studies, antibody production, or functional assays. Emerging evidence links KIAA1201 to interactions with proteins involved in endoplasmic reticulum homeostasis and stress responses, such as VAPB, though precise mechanisms remain unclear. Its recombinant version enables exploration of binding partners, post-translational modifications, and therapeutic potential. Current research focuses on clarifying its physiological roles and pathological relevance, leveraging recombinant protein tools to address gaps in understanding its contributions to development, tissue homeostasis, or disease pathways.
×
