| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA0562 |
| Uniprot No | O60308 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-554aa |
| 活性数据 | MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQEIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCDNEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDESNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDLAFDMYQDPEVAQIIRKLDERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEVEKRCAVEKEDFDLAKEKKQQMEQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTENQFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERSLPAIRKHYGEAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSYREDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKLSKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQV |
| 分子量 | 89.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA0562蛋白的示例参考文献(请注意，这些为模拟示例，实际文献需通过学术数据库验证)：
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1. **文献名称**: "KIAA0562 as a novel regulator of ubiquitin ligase complexes in DNA repair"
**作者**: Smith, J. et al. (2015)
**摘要**: 研究了重组人KIAA0562蛋白在DNA损伤修复中的作用，证明其通过与E3泛素连接酶复合物相互作用，促进靶蛋白的泛素化修复通路。
2. **文献名称**: "Structural characterization of recombinant human KIAA0562 and its interaction with cellular kinases"
**作者**: Brown, A. et al. (2017)
**摘要**: 通过X射线晶体学解析了重组KIAA0562的蛋白结构，揭示了其激酶结合域的构象，并发现其参与MAPK信号通路的调控。
3. **文献名称**: "KIAA0562 gene silencing impairs neuronal development in vitro"
**作者**: Zhang, L. et al. (2019)
**摘要**: 利用重组KIAA0562蛋白的体外实验，验证了其在神经元突触形成中的功能，基因沉默导致神经元分化异常。
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**建议**：如需真实文献，请访问 **PubMed** 或 **Google Scholar**，使用关键词“recombinant KIAA0562”、“KIAA0562 function”或“ZNF451”(可能的别名)进行检索，并筛选近年研究以获取最新进展。
Recombinant human KIAA0562 protein is derived from the KIAA0562 gene, initially identified through large-scale sequencing projects aimed at characterizing unknown human genes. This gene, located on chromosome 1 (1p36.22), encodes a protein with predicted enzymatic domains, including a conserved ATP/GTP-binding site, suggesting potential roles in energy-dependent cellular processes. Although its precise biological function remains under investigation, KIAA0562 has been linked to neurodevelopmental pathways and cellular stress responses. Studies implicate it in microtubule dynamics and ciliary function, with variants associated with intellectual disability and ciliopathies. Its expression is observed in multiple tissues, notably enriched in the brain, underscoring possible neural significance.
The recombinant protein is typically produced in bacterial or mammalian systems to enable functional studies. Structural analyses reveal post-translational modification sites, hinting at regulatory mechanisms. Current research focuses on clarifying its interactome, catalytic activity, and involvement in diseases like glioblastoma, where altered expression correlates with tumor progression. Despite progress, KIAA0562's full mechanistic profile and therapeutic potential remain open questions, driving ongoing exploration in molecular and cellular contexts.
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