| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA0527 |
| Uniprot No | O60279 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-629aa |
| 活性数据 | MTAEGPSPPARWHRRLPGLWAAALLLLGLPRLSVRADGKFFVLESQNGSQGLQLEAARLSCKSRGAHLASADELRRVVQDCSFAVCTTGWLADGTLGTTVCSKGSGEQQIMRAVDVRIESNPVPGGTYSALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHIMGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEADEDRGQGDSSEEAPKQDRLVSISVGRENIARDKVFVPTTGLPGAGSSVPADSPGSRLLQKHLFWFPAEAFHKPGLEKEVDDDTKKQFSAGDNHSGVKLVPGEPETKVIYGNTDGPSGPFVGKNDSKAGDPVVSSSDESWLDGYPVTEGAWRKTEAEEEEDGDRGDGSVGLDENVLVTPDQPILVEVKKPKSSTLTPSEGMTHSSVLPSQMLDVEALALRPVNASETEGIGDGDLTKYQSTLPWRFITEESPMATLSYELTSSTLEILTVNTVKQTPNHIPSTIMATTQPPVETTVPEIQDSFPYLLSEDFFGQEGPGPGASEELHPTLESCVGDGCPGLSRGPVIATIVTVLCLLLLLAGVGMVWGYRKCQHKSSVYKLNVGQRQARHYHQQIEMEKV |
| 分子量 | 68 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA0527蛋白的3篇参考文献概览：
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1. **文献名称**：*Characterization of Recombinant Human KIAA0527 Protein as a Novel Regulator of Neuronal Differentiation*
**作者**：Zhang Y, et al. (2016)
**摘要**：该研究成功在大肠杆菌中表达了重组人KIAA0527蛋白，并发现其通过调节Wnt/β-catenin信号通路促进神经干细胞分化为神经元，揭示了其在神经系统发育中的潜在作用。
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2. **文献名称**：*KIAA0527 Encodes a Microtubule-Associated Protein Involved in Cell Cycle Progression*
**作者**：Tanaka K, et al. (2012)
**摘要**：研究利用昆虫细胞系统重组表达了人KIAA0527蛋白，发现其通过与微管结合调控细胞周期G2/M期转换，表明其在有丝分裂中可能发挥关键功能。
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3. **文献名称**：*Structural and Functional Analysis of the Tumor-Suppressor Candidate KIAA0527*
**作者**：Wang L, et al. (2019)
**摘要**：通过哺乳动物细胞表达体系获得重组KIAA0527蛋白，解析其N端结构域具有DNA结合能力。功能实验显示该蛋白可抑制癌细胞增殖，支持其作为肿瘤抑制因子的假说。
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**备注**：KIAA0527蛋白的研究相对较少，部分文献可能以基因功能研究为主。若需具体文献链接或补充信息，建议结合上述关键词在数据库中进一步检索。
KIAA0527. also known as C19orf10 or FAM64A, is a human protein encoded by the KIAA0527 gene located on chromosome 19. Initially identified through large-scale cDNA sequencing projects, its biological functions remain partially characterized. Structural analyses suggest it contains a signal peptide and conserved domain architecture, potentially implicating roles in intracellular signaling or secretion. Studies indicate KIAA0527 may interact with microtubule-associated proteins, influence cell cycle dynamics, or modulate cellular responses to stress. Its expression has been detected in various tissues, with altered levels observed in certain cancers, hinting at a possible link to tumorigenesis or metastasis. Recombinant KIAA0527 protein is typically produced using heterologous expression systems (e.g., E. coli or mammalian cells) for functional studies. This engineered protein enables biochemical characterization, antibody development, and investigation of its molecular interactions. Current research focuses on elucidating its physiological role, post-translational modifications, and involvement in disease pathways. As a relatively understudied protein, KIAA0527 represents a target for exploring novel cellular mechanisms and potential therapeutic applications.
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