| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ILDR1 |
| Uniprot No | Q86SU0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-502aa |
| 氨基酸序列 | MAWPKLPAPWLLLCTWLPAGCLSLLVTVQHTERYVTLFASIILKCDYTTSAQLQDVVVTWRFKSFCKDPIFDYYSASYQAALSLGQDPSNDCNDNQREVRIVAQRRGQNEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIEAPGDTSGDPDKEVKLIVLHWLTVIFIILGALLLLLLIGVCWCQCCPQYCCCYIRCPCCPAHCCCPEEDLSLPSSLPQMPMTQTTNQPPIANGVLEYLEKELRNLNLAQPLPPDLKGRFGHPCSMLSSLGSEVVERRIIHLPPLIRDLSSSRRTSDSLHQQWLTPIPSRPWDLREGRSHHHYPDFHQELQDRGPKSWALERRELDPSWSGRHRSSRLNGSPIHWSDRDSLSDVPSSSEARWRPSHPPFRSRCQERPRRPSPRESTQRHGRRRRHRSYSPPLPSGLSSWSSEEDKERQPQSWRAHRRGSHSPHWPEEKPPSYRSLDITPGKNSRKKGSVERRSEKDSSHSGRSVVI |
| 分子量 | 84.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ILDR1蛋白的示例参考文献(仅供格式参考，具体文献需通过学术数据库查询)：
1. **文献名称**：*Structural and functional characterization of recombinant human ILDR1 protein*
**作者**：Smith A, et al.
**摘要**：该研究成功表达并纯化了重组人ILDR1蛋白，通过X射线晶体学解析其三维结构，揭示其免疫球蛋白样结构域的关键功能区域，并验证其与细胞间连接蛋白的相互作用。
2. **文献名称**：*ILDR1 mediates cell barrier formation via tricellular tight junctions*
**作者**：Tanaka K, et al.
**摘要**：研究证明重组人ILDR1蛋白在三细胞紧密连接中起调控作用，通过体外细胞模型发现其缺失导致上皮屏障功能破坏，提示ILDR1在维持组织完整性中的重要性。
3. **文献名称**：*Association of ILDR1 mutations and recombinant protein rescue in hearing loss models*
**作者**：Wang Y, et al.
**摘要**：利用重组人ILDR1蛋白在小鼠模型中验证了特定突变导致听力障碍的机制，并证明外源性ILDR1可部分恢复耳蜗毛细胞的正常功能。
4. **文献名称**：*ILDR1 as a novel target in cancer therapy: Insights from recombinant protein-based assays*
**作者**：Liu X, et al.
**摘要**：通过重组ILDR1蛋白的体外实验发现其在调控肿瘤细胞迁移中的作用，提出靶向ILDR1可能抑制癌症转移的潜在策略。
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**注**：以上文献信息为模拟示例，实际文献请通过PubMed、Web of Science或Google Scholar检索关键词“recombinant human ILDR1 protein”获取。
Recombinant human ILDR1 (Immunoglobulin-like domain-containing receptor 1) is a transmembrane protein belonging to the immunoglobulin superfamily. Initially identified for its role in the development and maintenance of the cochlea, ILDR1 is critical for proper hearing function, as mutations in its encoding gene are linked to autosomal recessive deafness. Structurally, ILDR1 contains an extracellular immunoglobulin (Ig) domain, a single-pass transmembrane region, and a cytoplasmic tail, suggesting involvement in cell-cell adhesion and signaling. While its precise molecular mechanisms remain under investigation, ILDR1 interacts with other proteins at tricellular tight junctions in epithelial and endothelial cells, potentially regulating barrier integrity and polarity.
Recent studies implicate ILDR1 in broader physiological and pathological contexts, including cancer. It may influence tumor microenvironments by modulating immune responses or cell survival pathways. Recombinant ILDR1 protein, typically produced in mammalian expression systems (e.g., HEK293 or CHO cells), enables functional studies to dissect its interactions, signaling roles, and therapeutic potential. Purified via affinity chromatography, it serves as a tool for biochemical assays, antibody development, and exploring ILDR1-related pathways in hearing loss, epithelial disorders, or cancer. Ongoing research aims to clarify its dual roles in tissue-specific homeostasis and disease progression.
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