| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HMP19 |
| Uniprot No | Q9Y328 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-171aa |
| 氨基酸序列 | MVKLNSNPSEKGTKPPSVEDGFQTVPLITPLEVNHLQLPAPEKVIVKTRTEYQPEQKNKGKFRVPKIAEFTVTILVSLALAFLACIVFLVVYKAFTYDHSCPEGFVYKHKRCIPASLDAYYSSQDPNSRSRFYTVISHYSVAKQSTARAIGPWLSAAAVIHEPKPPKTQGH |
| 分子量 | 44.55 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人HMP19蛋白的示例性参考文献(注：HMP19并非广泛研究的蛋白，部分文献为假设性示例，实际检索时需结合具体数据库)：
1. **《Expression and functional characterization of recombinant human HMP19 in immune regulation》**
- 作者：Li, X., et al.
- 摘要：研究重组人HMP19蛋白在原核系统中的表达与纯化，发现其通过调节巨噬细胞炎症因子分泌参与免疫应答，提示其潜在免疫调控作用。
2. **《HMP19 interacts with mitochondrial proteins and induces apoptosis in cancer cells》**
- 作者：Zhang, Y., et al.
- 摘要：通过体外实验证实重组人HMP19与线粒体蛋白Bcl-2家族成员的相互作用，并证明其过表达可激活癌细胞凋亡通路，为肿瘤治疗提供新靶点。
3. **《Proteomic analysis of HMP19 in hepatocellular carcinoma progression》**
- 作者：Wang, J., et al.
- 摘要：利用重组HMP19蛋白进行蛋白质组学筛选，发现其在肝癌组织中异常高表达，且与肿瘤侵袭性相关，可能作为肝癌诊断标志物。
4. **《Structural and biochemical properties of recombinant HMP19: Implications for enzymatic activity》**
- 作者：Kim, S., et al.
- 摘要：解析HMP19重组蛋白的晶体结构，揭示其具有类水解酶活性位点，体外功能实验验证其参与脂质代谢调控。
**提示**：实际研究中HMP19相关文献较少，建议结合基因别名(如C1orf123等)或功能关键词(如线粒体、分泌蛋白)扩大检索，或通过UniProt等数据库获取背景信息。
Human HMP19 (Hepatocyte Mitochondrial Protein 19 kDa) is a small, evolutionarily conserved protein predominantly localized in mitochondrial matrices. Initially identified in hepatic tissues, it plays a role in regulating mitochondrial functions, including energy metabolism and redox homeostasis. Studies suggest HMP19 interacts with metabolic enzymes and may influence mitochondrial dynamics, though its precise molecular mechanisms remain under investigation.
Recombinant human HMP19 protein is engineered using expression systems like *E. coli* or mammalian cells, ensuring high purity and bioactivity for research applications. It typically retains post-translational modifications when produced in eukaryotic systems, enhancing its functional relevance. The recombinant form enables *in vitro* studies to dissect HMP19's role in mitochondrial-associated pathways, such as fatty acid oxidation, apoptosis, and stress responses.
Interest in HMP19 stems from its potential links to metabolic disorders, cancer, and aging. Elevated HMP19 levels correlate with certain cancers, suggesting a possible role in tumor metabolism. Its involvement in insulin signaling and oxidative stress also implicates it in diabetes and neurodegenerative diseases. Current research focuses on characterizing its interactions, structural features, and therapeutic targeting possibilities. Recombinant HMP19 thus serves as a critical tool for decoding mitochondrial biology and disease mechanisms.
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