关键信息
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基因名
aTRX
- 应用
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别名
aTRX；RAD54L；XH2；Transcriptional regulator ATRX
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P46100
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表达区间
2311-2410aa
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氨基酸序列
FNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKE NMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILM
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
aTRX, a variant of thioredoxin, is a small redox-active protein that plays a crucial role in cellular processes, including regulating oxidative stress and facilitating protein folding. Research on aTRX has gained attention due to its potential therapeutic applications in various diseases, especially those related to oxidative damage and inflammation. The original thioredoxin proteins have been extensively studied for their role in redox biology, but aTRX stands out because of its unique structural features and enhanced stability. These properties make aTRX a promising candidate for recombinant protein engineering, where it can be utilized as a fusion partner to improve the solubility and stability of other proteins in biotechnological and pharmaceutical applications. Additionally, understanding the molecular mechanisms of aTRX's action may lead to innovative strategies for treating conditions such as cancer, neurodegenerative diseases, and cardiovascular disorders, where redox imbalances play a significant role. The ongoing exploration of aTRX and its recombinant forms may not only enhance our grasp of redox biology but also pave the way for the development of novel therapeutic interventions.
