关键信息
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基因名
KIBRA
- 应用
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别名
KIBRA；KIAA0869；Protein KIBRA
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IX03
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表达区间
655-783aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSEAVGATR IQIALKYDEK NKQFAILIIQ LSNLSALLQQ QDQKVNIRVA VLPCSESTTC LFRTRPLDASDTLVFNEVFW VSMSYPALHQ KTLRVDVCTT DRSHLEECLG GAQISLAEVC RSGERSTRWY NL
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分子量
17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KIBRA (Kidney and Brain Anion Channel) is a protein that has gained significant attention in recent years due to its involvement in various cellular processes, including memory and synaptic plasticity, as well as its potential role in kidney function. Originally identified through its association with the brain, KIBRA has been linked to mechanisms underlying long-term potentiation, making it a potential key player in cognitive processes. Additionally, studies suggest that KIBRA is involved in regulating epithelial sodium channels, which are crucial for maintaining sodium balance in the kidneys. The interest in KIBRA as a target for therapeutic interventions has been heightened by its association with various diseases, including Alzheimer's disease and chronic kidney disease. Researchers are actively investigating the structural and functional properties of KIBRA through techniques such as protein purification and characterization, aiming to elucidate its biological roles and potential as a biomarker or therapeutic target. Overall, the reconstitution and detailed study of KIBRA protein are crucial for understanding its complex role in physiology and pathology, paving the way for novel approaches in treating related disorders.
