| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | GIOT-1 |
| Uniprot No | Q8TAF7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-563aa |
| 氨基酸序列 | MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS KPAVISSLEQ GKEPWMVVRE ETGRWCPGTW KTWGFHNNFL DNNEATDINA DLASRDEPQK LSPKRDIYET ELSQWVNMEE FKSHSPERSI FSAIWEGNCH FEQHQGQEEG YFRQLMINHE NMPIFSQHTL LTQEFYDREK ISECKKCRKI FSYHLFFSHH KRTHSKELSE CKECTEIVNT PCLFKQQTIQ NGDKCNECKE CWKAFVHCSQ LKHLRIHNGE KRYECNECGK AFNYGSELTL HQRIHTGEKP YECKECGKAF RQRSQLTQHQ RLHTGEKPYE CKQCGKAFIR GFQLTEHLRL HTGEKPYECK ECGKTFRHRS HLTIHQRIHT GEKPYECREC GKAFSYHSSF SHHQKIHSGK KPYECHECGK AFCDGLQLTL HQRIHTGEKP YECKECGKTF RQCSHLKRHQ RIHTGEKPHE CMICGKAFRL HSHLIQHQRI HTGEKPYECK ECGKAFSYHS SFSHHQRIHS GKKPYQCGKA FNHRLQLNLH QTLHTGEKPV RFPLLPPHPS LAS |
| 分子量 | 66.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于假设的3-4条关于重组人GIOT-1蛋白的参考文献示例（注：实际文献可能需要进一步验证名称正确性或存在性）：
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1. **文献名称**: *Molecular cloning and characterization of human GIOT-1: Interaction with G proteins in T cell signaling*
**作者**: K. Hayashi, Y. Shimizu, et al.
**摘要**: 本文首次报道了GIOT-1基因的克隆及重组蛋白的表达。研究表明，GIOT-1在T细胞中通过结合G蛋白亚基参与信号转导，并可能调节免疫反应。
2. **文献名称**: *Functional analysis of recombinant human GIOT-1 in cellular signaling pathways*
**作者**: H. Nakajima, M. Tanaka
**摘要**: 通过重组GIOT-1蛋白的体外实验，揭示了其在MAPK/ERK通路中的调控作用，并证实其与膜受体偶联的分子机制。
3. **文献名称**: *Structural insights into GIOT-1 protein interactions via recombinant co-expression studies*
**作者**: M. Yamamoto, T. Sato
**摘要**: 利用重组GIOT-1与β-arrestin的共表达技术，解析了二者结合的结构域，为设计靶向GIOT-1的抑制剂提供了依据。
4. **文献名称**: *Role of recombinant GIOT-1 in transcriptional regulation: Implications for autoimmune diseases*
**作者**: A. Saito, R. Kobayashi
**摘要**: 研究重组GIOT-1对NF-κB通路的调控作用，提示其可能通过核转录因子影响炎症基因表达，与自身免疫疾病相关。
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**注意**：以上文献为示例性内容。若检索不到相关成果，建议确认“GIOT-1”名称的正确性（如是否为GIT1或相似蛋白的拼写变体），并尝试扩展检索关键词或领域。
Recombinant human GIOT-1 protein is a genetically engineered biomolecule derived from the human GIOT-1 gene, which encodes a protein implicated in various cellular processes. Initially identified through genomic and proteomic studies, GIOT-1 is suggested to play roles in intracellular signaling, immune regulation, or structural organization, though its precise biological functions remain under investigation. Structurally, GIOT-1 may feature conserved domains associated with protein-protein interactions or enzymatic activity, which are critical for its hypothesized involvement in pathways like cell adhesion, apoptosis, or transcriptional modulation. The recombinant form is typically produced in expression systems such as E. coli or mammalian cells, ensuring high purity and scalability for research. Its applications span in vitro assays, antibody development, and functional studies to elucidate molecular mechanisms in diseases like cancer or neurological disorders. Interest in GIOT-1 also stems from its potential as a therapeutic target or diagnostic biomarker. However, further characterization is needed to clarify its physiological roles, interaction networks, and relevance to human pathologies. Current research focuses on delineating its structure-function relationships and validating its contributions to specific disease models, leveraging recombinant GIOT-1 as a tool to advance biomedical discovery.
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