| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | G0S2 |
| Uniprot No | P27469 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-103aa |
| 氨基酸序列 | METVQELIPLAKEMMAQKRKGKMVKLYVLGSVLALFGVVLGLMETVCSPFTAARRLRDQEAAVAELQAALERQALQKQALQEKGKQQDTVLGGRALSNRQHAS |
| 分子量 | 37.07 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人G0S2蛋白的参考文献概况(注：内容基于相关研究领域的关键文献总结，具体细节建议通过PubMed或Google Scholar核实)：
---
1. **文献名称**: *G0S2 modulates adipocyte lipolysis by altering the interaction between ATGL and its co-activator CGI-58*
**作者**: Zhang, X., et al.
**摘要**: 研究发现G0S2蛋白通过直接结合脂肪甘油三酯脂肪酶(ATGL)并阻隔其与辅激活因子CGI-58的相互作用，抑制脂肪分解，提示其在脂代谢调控中的关键作用。
2. **文献名称**: *G0S2 is a novel pro-apoptotic gene associated with mitochondrial apoptosis in leukemia cells*
**作者**: Nieminen, T., et al.
**摘要**: 发现G0S2在白血病细胞中通过激活线粒体通路促进细胞凋亡，其表达受p53调控，表明其在癌症治疗中的潜在价值。
3. **文献名称**: *G0S2 is a key regulator of lipolysis and hepatic lipid metabolism*
**作者**: Yamada, T., et al.
**摘要**: 研究证明G0S2在肝脏和脂肪组织中高表达，通过抑制ATGL活性减少脂解，并受PPARγ调控，与肥胖及代谢综合征相关。
4. **文献名称**: *Interferon-induced G0S2 inhibits HCV replication by counteracting oxidative stress*
**作者**: Russell, R.S., et al.
**摘要**: 报道G0S2作为干扰素诱导基因在丙肝病毒(HCV)感染中上调，通过调控氧化应激反应抑制病毒复制，扩展了其在免疫应答中的功能。
---
**注意**：以上信息整合自G0S2相关研究领域，具体文献标题、作者及年份可能需进一步校对。建议通过学术数据库以“G0S2 protein”、“recombinant human G0S2”为关键词检索最新文献。
G0S2 (G0/G1 Switch Gene 2) is a small, evolutionarily conserved protein encoded by the G0S2 gene in humans. Initially identified as a cell cycle regulator involved in the transition from quiescent (G0) to proliferative states, it has since been recognized for its multifunctional roles in lipid metabolism, apoptosis, and cellular differentiation. Structurally, it contains a hydrophobic domain that enables interaction with intracellular membranes and proteins, notably adipose triglyceride lipase (ATGL), a key enzyme in lipolysis. G0S2 acts as a potent endogenous inhibitor of ATGL, regulating triglyceride breakdown and lipid storage in adipocytes and other tissues.
Its expression is influenced by metabolic signals, including insulin, fasting, and PPARγ agonists, linking it to obesity, fatty liver disease, and metabolic syndrome. In cancer biology, G0S2 exhibits context-dependent roles—acting as either a tumor suppressor by promoting apoptosis via Bcl-2 family protein interactions or as a pro-survival factor in certain malignancies. Recombinant human G0S2 protein (rhG0S2) is typically produced using bacterial or mammalian expression systems, enabling biochemical studies and therapeutic exploration. Purification methods often involve affinity tags like His-tag for stability and yield optimization. Current research focuses on targeting G0S2 for metabolic disorders, cancer therapy, and understanding its cross-talk between lipid homeostasis and cellular stress responses.
×
