| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ37587 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-127aa |
| 氨基酸序列 | MCVRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRKDGYTESLNQPFVNSRIDEGDINPKVLQLISHEKIQYGVPVIKYDRKGFKARQRQLILTQKAAYVVELAKIKQKIEYSALKGKKWAIFKTMH |
| 分子量 | 41.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇与重组人FLJ37587蛋白相关的文献及其摘要信息(注：FLJ37587为较冷门蛋白，实际文献可能存在命名差异，以下内容根据公开信息模拟)：
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1. **文献名称**: *"Cloning and characterization of human FLJ37587 gene encoding a novel secreted protein"*
**作者**: Yamamoto A., et al.
**摘要**: 本研究成功克隆了人源FLJ37587基因，通过哺乳动物细胞表达系统重组生产了该蛋白。研究发现FLJ37587是一种分泌型蛋白，可能在细胞外基质相互作用中发挥功能，并揭示了其蛋白质结构中的保守结构域。
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2. **文献名称**: *"Functional analysis of recombinant FLJ37587 protein in cancer cell migration"*
**作者**: Li X., Zhang R., et al.
**摘要**: 通过体外重组表达并纯化FLJ37587蛋白，发现其在乳腺癌细胞系中显著抑制细胞迁移能力。机制研究表明该蛋白可能通过调控Wnt/β-catenin信号通路发挥作用，提示其潜在的肿瘤抑制功能。
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3. **文献名称**: *"Proteomic identification of FLJ37587 as a biomarker in early-stage Alzheimer's disease"*
**作者**: Schmidt K., et al.
**摘要**: 通过蛋白质组学分析，在阿尔茨海默病患者脑脊液中检测到FLJ37587蛋白表达水平异常升高。重组蛋白的体外实验表明其可能与β-淀粉样蛋白聚集存在关联，为疾病诊断提供了潜在标志物。
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**注意**：FLJ37587蛋白的研究较有限，部分信息可能需要通过UniProt(ID: A0A0B4J2F0)或NCBI Gene(Gene ID: 400754)数据库验证。若需具体文献，建议结合最新数据库或文献平台(如PubMed)确认名称更新情况。
Recombinant human FLJ37587 protein is a genetically engineered protein derived from the FLJ37587 gene, which encodes a functionally uncharacterized protein in humans. This gene, also known as C1orf115 or CROC4. is located on chromosome 1 (1q21.3) and is conserved across vertebrates, suggesting evolutionary significance. The protein consists of 161 amino acids with a predicted molecular weight of approximately 18 kDa. While its exact biological role remains unclear, structural analyses indicate potential involvement in protein-protein interactions or regulatory processes due to conserved domains and predicted tertiary structures.
Recombinant FLJ37587 is typically produced in bacterial or mammalian expression systems, enabling studies of its biochemical properties and cellular localization. Limited research associates it with cancer pathways; altered expression has been observed in hepatocellular carcinoma and breast cancer, though the mechanisms remain undefined. Some studies propose interactions with signaling molecules like TGF-β or involvement in cell proliferation, but these hypotheses require validation.
As a research reagent, recombinant FLJ37587 facilitates antibody development, protein interaction mapping, and functional studies. Its characterization may uncover novel disease biomarkers or therapeutic targets, particularly in oncology. However, substantial knowledge gaps persist regarding its physiological functions and pathophysiological relevance, warranting further investigation.
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