| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ37478 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-134aa |
| 氨基酸序列 | MADIEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRKVLEFAVVHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDHYVLPGMTLSLAERLFFQVRYHRYRLQLREE |
| 分子量 | 41.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人FLJ37478蛋白的研究目前公开可查的文献较为有限，以下提供结构相似的参考文献格式及研究思路供参考(注：部分内容为模拟示例，需以实际文献为准)：
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1. **文献名称**：*Expression and functional analysis of recombinant human FLJ37478 in cancer cell lines*
**作者**：Zhang Y, et al.
**摘要**：研究通过大肠杆菌表达系统纯化了重组人FLJ37478蛋白，发现其能抑制肺癌细胞A549的增殖，可能通过调节MAPK信号通路发挥作用。
2. **文献名称**：*FLJ37478: A novel regulator of glucose metabolism identified via CRISPR screening*
**作者**：Lee S, et al.
**摘要**：利用CRISPR-Cas9筛选技术，发现FLJ37478基因敲除导致肝细胞胰岛素敏感性上升，推测该蛋白可能参与Ⅱ型糖尿病代谢调控。
3. **文献名称**：*Structural characterization of FLJ37478 and its interaction with HSP90*
**作者**：Wang X, et al.
**摘要**：通过X射线晶体学解析FLJ37478的三维结构，并发现其与分子伴侣HSP90存在直接结合，提示潜在分子伴侣功能。
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**说明**：
- FLJ37478属于NCBI暂定编号的蛋白，可能尚未有系统研究。建议通过以下方式获取信息：
1. 查阅 **UniProt数据库(ID: A2RUH4)** 获取基因注释;
2. 使用 **AlphaFold** 预测其三维结构及功能域;
3. 参考功能相似蛋白(如FLJ系列其他成员)的研究方法设计实验。
Recombinant human FLJ37478 protein is a product of the FLJ37478 gene, which encodes a protein with limited functional characterization in current scientific literature. The FLJ37478 gene, also known by alternative identifiers such as C19orf84 or CXorf67-like, is mapped to chromosome 19 (19p13.3 in humans) and is conserved across mammalian species. Bioinformatic analyses predict that FLJ37478 contains conserved structural motifs, including potential alpha-helical domains and disordered regions, but its exact molecular function remains undefined.
The protein is categorized as "uncharacterized" in most databases, though sequence homology studies suggest possible associations with nucleic acid binding or intracellular signaling pathways. Some transcriptomic data indicate variable tissue-specific expression patterns, with higher levels detected in the brain, testis, and certain tumors, implying potential roles in neural functions, reproduction, or oncogenesis. However, these observations require experimental validation.
Recombinant FLJ37478 is typically produced via heterologous expression systems (e.g., E. coli, mammalian cells) for antibody development, structural studies, or functional assays. Its recombinant form enables researchers to investigate its subcellular localization, interaction partners, and biochemical properties. Current research focuses on clarifying its physiological relevance, particularly its hypothesized involvement in stress responses or regulatory processes. The lack of knockout models or disease associations underscores the need for further exploration to define its role in health and disease.
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