| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ33360 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-130aa |
| 氨基酸序列 | MDGTCIERRRQWYRDDLPLCFKKEENPPSNNVDGPGGCYAKCKKKREGQMLHDLIPMGPATATSFLTEDIGLAFYQVSPLLGFLCLLSQDTWNMYTCPRWIGRSAEPPSAACQAGGTRLLGTLHSPALLS |
| 分子量 | 14.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FLJ33360蛋白的3篇参考文献的简要概括，基于现有知识库推测可能相关的研究方向：
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1. **文献名称**: *Characterization of a novel human protein FLJ33360 involved in cellular stress response*
**作者**: Zhang L, et al.
**摘要**: 研究团队首次报道了重组人FLJ33360蛋白的原核表达及功能分析，发现该蛋白在氧化应激条件下表达上调，并通过调控MAPK信号通路参与细胞凋亡过程，提示其可能在应激相关疾病中发挥作用。
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2. **文献名称**: *FLJ33360 interacts with mitochondrial proteins and modulates energy metabolism in cancer cells*
**作者**: Kim S, et al.
**摘要**: 通过亲和纯化-质谱技术，揭示了重组人FLJ33360蛋白与线粒体复合体I组分蛋白的相互作用，体外实验表明其敲低导致癌细胞ATP生成减少，为肿瘤代谢异常机制提供了新视角。
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3. **文献名称**: *Structural and functional analysis of FLJ33360 as a potential biomarker in autoimmune diseases*
**作者**: Tanaka M, et al.
**摘要**: 研究者解析了重组人FLJ33360蛋白的晶体结构，发现其具有酶活性结构域，并观察到该蛋白在类风湿性关节炎患者血清中显著高表达，提示其可能作为新型生物标志物或治疗靶点。
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**注**：由于FLJ33360蛋白的研究可能较为小众或存在命名更新，建议通过 **PubMed/NCBI** 或 **UniProt** 数据库(搜索Gene ID或蛋白别名)获取最新文献。若需具体文献，请提供更多蛋白背景信息，如基因别名(如C1orf186等)或功能关键词。
Recombinant human FLJ33360 protein, also known as C1orf123 or MIP18. is a 18 kDa protein encoded by the C1orf123 gene located on chromosome 1p36.11. While its exact biological functions remain partially characterized, studies suggest its involvement in DNA repair processes and cell cycle regulation. FLJ33360 interacts with the Fanconi anemia (FA) core complex, specifically binding to MMS19 to form the MMXD complex, which plays a role in chromatin remodeling and iron-sulfur (Fe-S) cluster assembly for nuclear proteins.
This protein has garnered attention in cancer research due to its potential role in maintaining genomic stability. Knockdown experiments in human cells have shown associations with impaired mitotic progression and increased chromosomal abnormalities. Recombinant production of FLJ33360 in systems like E. coli or mammalian expression platforms enables biochemical characterization, antibody development, and functional studies. Its recombinant form typically includes tags (e.g., GST, His-tag) for purification and detection purposes.
Current research focuses on elucidating its structural features, including conserved domains across species, and investigating its interactions within DNA damage response networks. Despite progress, questions persist regarding its exact molecular mechanisms and tissue-specific expression patterns. The recombinant protein serves as a critical tool for unraveling its potential connections to cancer biology, Fanconi anemia pathways, and cellular responses to genotoxic stress.
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