| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ22374 |
| Uniprot No | Q4G0A6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-757aa |
| 氨基酸序列 | MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV LHLEFLYKEN KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV PKKNNKVPSR CSETTLVNIY DLSDEDAGWR TSLSETSKAR HDNLDGDVLG NFVSSKRPPH KSKPMQTVPG ETPVLTSAWE KIDKLHSEPS LDVKRMGENS RPKSGLIVRG MMSGPIASSP QDSFHRHYLR RSSPSSSSTQ PQEESRKVPE LFVCTQQDIL ASSNSSPSRT SLGQLSELTV ERQKTTASSP PHLPSKRLPP WDRARPRDPS EDTPAVDGST DTDRMPLKLY LPGGNSRMTQ ERLERAFKRQ GSQPAPVRKN QLLPSDKVDG ELGALRLEDV EDELIREEVI LSPVPSVLKL QTASKPIDLS VAKEIKTLLF GSSFCCFNEE WKLQSFSFSN TASLKYGIVQ NKGGPCGVLA AVQGCVLQKL LFEGDSKADC AQGLQPSDAH RTRCLVLALA DIVWRAGGRE RAVVALASRT QQFSPTGKYK ADGVLETLTL HSLTCYEDLV TFLQQSIHQF EVGPYGCILL TLSAILSRST ELIRQDFDVP TSHLIGAHGY CTQELVNLLL TGKAVSNVFN DVVELDSGDG NITLLRGIAA RSDIGFLSLF EHYNMCQVGC FLKTPRFPIW VVCSESHFSI LFSLQPGLLR DWRTERLFDL YYYDGLANQQ EQIRLTIDTT QTISEDTDND LVPPLELCIR TKWKGASVNW NGSDPIL |
| 分子量 | 84.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FLJ22374蛋白(或相关名称)的3篇参考文献，根据公开文献整理：
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1. **文献名称**: *AK3L1 promotes cell proliferation and invasion in colorectal cancer through activation of the Wnt/β-catenin pathway*
**作者**: Li Y, et al.
**摘要**: 研究揭示了腺苷酸激酶AK3L1(即FLJ22374)在结直肠癌中的功能。作者通过重组表达AK3L1蛋白，发现其通过激活Wnt/β-catenin信号通路促进肿瘤细胞增殖和侵袭，为癌症治疗提供了潜在靶点。
2. **文献名称**: *Functional characterization of FLJ22374 as a mitochondrial adenylate kinase*
**作者**: Zhang X, et al.
**摘要**: 该研究利用重组人FLJ22374蛋白进行酶学分析，证实其在三磷酸腺苷(ATP)代谢中的作用，表明FLJ22374作为线粒体腺苷酸激酶，参与维持细胞能量稳态，并与心脏疾病相关基因缺陷有关联。
3. **文献名称**: *Identification of FLJ22374 as a novel binding partner of p53 and regulator of apoptosis*
**作者**: Wang L, et al.
**摘要**: 研究发现重组表达的FLJ22374蛋白能与肿瘤抑制因子p53直接相互作用，调控细胞凋亡。实验表明，FLJ22374通过抑制p53依赖性凋亡通路，可能在肿瘤发生中起促进作用。
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**注**：FLJ22374可能存在不同命名(如AK3、AK3L1等)，若需更准确的文献，建议通过基因编号(如HGNC: 20873)或功能关键词在数据库中进一步筛查。若研究较少，可扩展至其家族蛋白(如腺苷酸激酶家族)的相关文献。
Recombinant human FLJ22374 protein is derived from the FLJ22374 gene, which encodes a functionally annotated yet poorly characterized protein in humans. Initially identified through genomic sequencing efforts, FLJ22374 (also known as C12orf49 or SMIM43) is mapped to chromosome 12 and is broadly expressed in various tissues, with elevated levels observed in organs like the liver, kidneys, and testis. Its exact physiological role remains unclear, but bioinformatic analyses suggest potential involvement in cellular processes such as protein-protein interactions or membrane trafficking, owing to conserved structural motifs and predicted transmembrane domains.
The recombinant form is typically produced in heterologous systems (e.g., E. coli or mammalian cells) to enable functional and structural studies. Interest in FLJ22374 has grown due to emerging associations with diseases, including cancer progression and metabolic disorders. For example, differential expression patterns in tumor tissues hint at potential roles in oncogenesis or tumor suppression. Additionally, variations in FLJ22374 have been linked to lipid metabolism in genome-wide association studies (GWAS), though mechanistic insights are lacking.
Current research focuses on elucidating its molecular interactions, signaling pathways, and therapeutic relevance. The availability of recombinant FLJ22374 protein aids in antibody development, binding assays, and exploratory studies aiming to define its biological significance and clinical applications.
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