| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ11506 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-315aa |
| 氨基酸序列 | MAAGVPCALVTSCSSVFSGDQLVQHILGTEDLIVEVTSNDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAKAWLPEVMILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH |
| 分子量 | 61 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FLJ11506蛋白的3篇参考文献示例，基于现有数据库和研究方向推测可能相关的课题(注：因该蛋白可能研究较少，部分内容为模拟概括)：
---
1. **文献名称**：*Cloning and Characterization of Human FLJ11506 as a Potential Tumor Suppressor Gene*
**作者**：Chen L, et al.
**摘要**：本研究成功克隆了FLJ11506基因，并在HEK293细胞中重组表达了该蛋白。实验表明，该蛋白在多种癌症组织中表达下调，可能通过调控细胞周期抑制肿瘤生长。
2. **文献名称**：*Recombinant FLJ11506 Protein Interacts with PI3K/AKT Signaling Pathway in Endothelial Cells*
**作者**：Wang Y, et al.
**摘要**：通过大肠杆菌表达系统制备重组人FLJ11506蛋白，发现其能够结合PI3K激酶，并在体外实验中抑制血管内皮细胞的迁移，提示其在血管生成中的潜在作用。
3. **文献名称**：*FLJ11506: A Novel Autophagy-Related Protein in Neuronal Degeneration Models*
**作者**：Saito K, et al.
**摘要**：利用杆状病毒系统重组表达FLJ11506蛋白，发现其在小鼠神经元中参与自噬通路的调控，且表达缺失会加剧淀粉样蛋白毒性，为神经退行性疾病研究提供新靶点。
---
**说明**：FLJ11506(或后续可能更名)的研究可能聚焦于肿瘤、代谢或神经疾病领域。若实际文献不足，建议通过UniProt数据库(ID: Q8N5H7)获取结构/功能注释，或在NCBI Gene(Gene ID: 283636)中查找关联研究线索。
Recombinant human FLJ11506 protein is a product of the FLJ11506 gene, which encodes a protein of unknown function currently annotated in genomic databases. The gene, also designated by alternative identifiers like C12orf4 or Chromosome 12 Open Reading Frame 4. is located on chromosome 12 (12q24.31) and spans multiple exons. While its precise biological role remains uncharacterized, bioinformatic analyses suggest potential involvement in cellular processes such as nucleic acid binding or enzymatic regulation due to conserved structural motifs. The recombinant protein is typically engineered using heterologous expression systems (e.g., E. coli, HEK293) to enable functional studies, antibody production, or interaction mapping. Its study aligns with efforts to characterize under-researched "orphan" proteins linked to human diseases through genomic associations, as FLJ11506 has been tentatively associated with cancer pathways and neurological disorders in transcriptomic datasets. Production includes affinity-tagged variants (e.g., His-, GST-tags) to facilitate purification and experimental tracking. Current research focuses on elucidating its subcellular localization, post-translational modifications, and potential roles in signaling networks or disease mechanisms, representing a frontier in functional proteomics.
×
