| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ11127 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-356aa |
| 氨基酸序列 | MAATRSPTRARERERSGAPAAGSDQVHSWMLATSQALDTVWRMAKGFVMLAVSFLVAAICYFRRLHLYSGHKLKWWIGYLQRKFKRNLSVEAEVDLLSYCAREWKGETPRNKLMRKAYEELFWRHHIKCVRQVRRDNYDALRSVLFQIFSQGISFPSWMKEKDIVKLPEKLLFSQGCNWIQQYSFGPEKYTGSNVFGKLRKYVELLKTQWTEFNGIRDYHKRGSMCNTLFSDAILEYKLYEALKFIMLYQVTEVYEQMKTKKVIPSLFRLLFSRETSSDPLSFMMNHLNSVGDTCGLEQIDMFILGYSLEVKIKVFRLFKFNSRDFEVCYPEEPLRDWPEISLLTENDRHYHIPVF |
| 分子量 | 64.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与重组人FLJ11127蛋白(亦称CIP2A)相关的研究文献摘要概览：
1. **"CIP2A promotes proliferation of human lung cancer cells by stabilizing MYC"**
*作者: Junttila MR, et al.*
该研究发现CIP2A(FLJ11127编码蛋白)通过抑制蛋白磷酸酶PP2A的活性，减少MYC蛋白的降解，从而促进肺癌细胞的增殖和肿瘤发生。
2. **"Role of CIP2A in cell cycle regulation and apoptosis"**
*作者: Böckelman C, et al.*
研究揭示了CIP2A在调控细胞周期G1/S转换中的作用，并证实其过表达抑制细胞凋亡，可能通过AKT信号通路促进恶性肿瘤进展。
3. **"CIP2A interacts with DNA damage response proteins"**
*作者: Khanna A, et al.*
发现CIP2A与ATM/ATR激酶存在相互作用，可能参与调控DNA损伤修复机制，提示其在基因组稳定性维护中的潜在功能。
*注：FLJ11127的官方命名现多采用CIP2A(全称：Cellular Inhibitor of PP2A)，建议以"CIP2A"为关键词检索最新文献。实际引用时请核实PubMed等数据库的完整信息。*
Recombinant human FLJ11127 protein is a product of the FLJ11127 gene, which encodes a poorly characterized protein initially identified through genomic sequencing efforts. This gene, also known as C1orf123 (Chromosome 1 Open Reading Frame 123), has limited functional annotation in public databases. The protein is predicted to contain 300 amino acids, with computational analyses suggesting potential involvement in intracellular signaling or regulation, though experimental validation remains sparse. Its name follows provisional nomenclature (FLJ = full-length cDNA of Japan) assigned during clone isolation.
Recombinant versions are typically produced in bacterial or mammalian expression systems for functional studies. Researchers utilize these proteins to investigate its interactions, subcellular localization, or role in diseases like cancer, where FLJ11127 mRNA has shown differential expression in some tumor datasets. Current applications include antibody development, biochemical assays (e.g., protein-protein interaction screens), and pathway analysis. However, the lack of definitive structural or functional data highlights a critical knowledge gap. Epigenetic studies note potential promoter methylation changes in neurological disorders, suggesting disease relevance. Efforts persist to elucidate its molecular mechanisms, leveraging recombinant protein tools to map binding partners or post-translational modifications. Its conservation across vertebrates hints at biological significance, yet comprehensive characterization remains pending.
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