| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ELMOD2 |
| Uniprot No | Q8IZ81 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-293aa |
| 氨基酸序列 | MFISLWEFFYGHFFRFWMKWLLRQMTGKCELQRIFDTYVGAQRTHRIENSLTYSKNKVLQKATHVVQSEVDKYVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGTNLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEFDKFWFEEEPESIMYFNLYREKFHEKIKGLLLDRNVALTLKV |
| 分子量 | 57.97 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ELMOD2蛋白的参考文献示例，内容基于领域相关研究综合概括：
1. **《ELMOD2 regulates mitochondrial dynamics and autophagy through ARF6 GTPase》**
*作者：Smith A. et al.*
摘要：研究利用重组人ELMOD2蛋白，发现其通过激活ARF6 GTP酶调控线粒体融合-分裂平衡，并影响自噬过程，提示其在细胞能量代谢中的关键作用。
2. **《Recombinant human ELMOD2 suppresses TLR4-mediated inflammatory signaling in macrophages》**
*作者：Zhang Y. et al.*
摘要：通过大肠杆菌表达系统制备重组人ELMOD2蛋白，实验表明其能抑制巨噬细胞中TLR4信号通路活化，减少促炎因子(如TNF-α、IL-6)释放，可能成为炎症性疾病治疗靶点。
3. **《Structural insights into the GTPase-activating function of ELMOD2》**
*作者：Brown C. et al.*
摘要：研究利用重组ELMOD2蛋白进行晶体结构解析，揭示其通过特定结构域结合ARF家族GTP酶并加速GTP水解，阐明了其作为非典型GAP(GTP酶激活蛋白)的分子机制。
4. **《ELMOD2 modulates antiviral immune response via STING-dependent interferon production》**
*作者：Lee H. et al.*
摘要：通过重组ELMOD2蛋白的体外功能实验，发现其与STING信号通路相互作用，增强Ⅰ型干扰素表达，为抗病毒免疫调节提供了新机制解释。
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注：以上文献标题及内容为示例性质，实际研究需参考具体已发表论文。建议通过PubMed、Web of Science等平台检索关键词“recombinant human ELMOD2”获取最新文献。
ELMOD2 (Engulfment and Cell Motility Domain-containing protein 2) is a member of the ELMO protein family, characterized by a conserved ELM2 domain and a C-terminal ELMO domain. Initially identified for its role in regulating cytoskeletal dynamics, ELMOD2 is implicated in modulating small GTPases, particularly those in the ARF (ADP-ribosylation factor) family, which are critical for vesicle trafficking, membrane remodeling, and cell migration. Unlike other ELMO proteins that function as guanine nucleotide exchange factors (GEFs) for ARF GTPases, ELMOD2 exhibits unique GTPase-activating protein (GAP) activity, facilitating the hydrolysis of GTP to GDP and thus inactivating ARF signaling.
Human ELMOD2 is broadly expressed, with higher levels observed in immune-related tissues like the spleen and lungs, suggesting a role in innate immunity. Studies link ELMOD2 to inflammatory responses, viral defense, and mitochondrial function. It has been associated with diseases such as asthma, rheumatoid arthritis, and cancer, where dysregulation of immune signaling or cellular motility contributes to pathogenesis. Notably, ELMOD2 interacts with mitochondrial proteins, influencing antiviral signaling pathways like MAVS (mitochondrial antiviral-signaling protein), highlighting its dual role in cellular structure and immune regulation.
Recombinant human ELMOD2 protein is engineered for in vitro studies to dissect its biochemical properties, structural motifs, and interactions. Its production enables research into therapeutic strategies targeting ARF-related pathways or immune disorders. Current research focuses on elucidating its precise molecular mechanisms and validating its potential as a biomarker or therapeutic target in chronic inflammatory and neoplastic diseases.
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