| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CTNND2 |
| Uniprot No | Q9UQB3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1225aa |
| 氨基酸序列 | MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLAAPQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYRNSYGAPAEDIKHNQVSAQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV |
| 分子量 | 132.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CTNND2(δ-catenin)蛋白的3篇代表性参考文献摘要，供参考：
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1. **文献名称**：δ-Catenin promotes prostate cancer cell survival and progression through AR-mediated transcription
**作者**：Lu Q, et al.
**摘要**：本研究揭示了重组人CTNND2蛋白在前列腺癌细胞中通过与雄激素受体(AR)相互作用，调控下游基因转录，从而促进肿瘤细胞增殖和转移。实验表明，CTNND2过表达可通过激活Wnt/β-catenin通路增强肿瘤侵袭性。
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2. **文献名称**：Purification and structural analysis of recombinant human δ-catenin reveals phosphorylation-dependent functional switches
**作者**：Meder L, et al.
**摘要**：文章报道了利用哺乳动物表达系统(HEK293细胞)成功表达并纯化重组人CTNND2蛋白，通过质谱和晶体学分析其磷酸化修饰位点，发现特定磷酸化状态调控CTNND2与E-cadherin的相互作用，影响细胞粘附功能。
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3. **文献名称**：δ-Catenin deficiency induces synaptic degeneration and behavioral deficits in Alzheimer’s disease models
**作者**：Sánchez-Sánchez R, et al.
**摘要**：该研究发现，重组CTNND2蛋白的缺失会破坏神经元突触结构，并加速淀粉样斑块沉积。通过体外重构实验，证明CTNND2与PSD-95的相互作用对突触可塑性至关重要，提示其作为阿尔茨海默病治疗的潜在靶点。
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**注**：CTNND2(δ-catenin)的研究多聚焦于神经系统发育障碍(如自闭症)和癌症转移领域。如需更具体文献，建议在PubMed或Web of Science数据库中按“recombinant CTNND2”或“delta-catenin expression”为关键词检索近年研究。
**Background on Recombinant Human CTNND2 Protein**
CTNND2 (Catenin Delta 2), also known as δ-catenin, is a member of the Armadillo repeat-containing protein family, primarily involved in cell-cell adhesion and synaptic regulation. It interacts with cadherins and other catenins (e.g., β-catenin) to stabilize adherens junctions, crucial for maintaining tissue architecture and neuronal connectivity. CTNND2 is highly expressed in the brain, particularly in postmitotic neurons, where it plays a role in dendrite formation, synapse development, and plasticity. Dysregulation of CTNND2 is linked to neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, as well as cancers like lung and breast malignancies.
Recombinant human CTNND2 protein is engineered in vitro using expression systems (e.g., E. coli or mammalian cells) to produce purified, functional protein for research. It enables studies on molecular mechanisms of cell adhesion, Wnt signaling modulation, and neuronal pathfinding. Researchers use it to investigate CTNND2’s role in disease models, screen therapeutic agents, or validate interactions via techniques like pull-down assays or immunohistochemistry. Its recombinant form ensures consistency and scalability, facilitating mechanistic insights into CTNND2-related pathways in health and disease.
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