| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CSRP2BP |
| Uniprot No | Q9H8E8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-782aa |
| 氨基酸序列 | MDSSIHLSSLISRHDDEATRTSTSEGLEEGEVEGETLLIVESEDQASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFFRFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHWTFLLGNRKKTSTWWSTVAGCLSVGSPMYFRSGAQEFGEPGWWKLVHNKPPTMKPEGEKLSASTLKIKAASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGFLDRSTSSTPVKFISRGRRPDVILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFSAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDDEMEGDGVIDPGMEYVPPPAGSVASGPVVGGRKKVRGPEQIKQEVESEEEKPDRMDIDSEDTDSNTSLQTRAREKRKPQLEKDTKPKEPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDQVVNAALLLVDGIYGAKEGGISRLPAGQATYRTTCQDFRILDRYQTSLPSRKGFRHQTTKFLYRLVGSEDMAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR |
| 分子量 | 115.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CSRP2BP蛋白的3篇参考文献示例(内容基于领域相关研究假设，具体文献需以实际检索为准)：
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1. **文献名称**：*Recombinant Human CSRP2BP Expression and Its Role in Transcriptional Regulation*
**作者**：Smith J, et al.
**摘要**：研究通过大肠杆菌系统表达了重组人CSRP2BP蛋白，验证其与转录因子(如MyoD)的相互作用，发现其通过调控肌肉分化相关基因的启动子活性，影响骨骼肌细胞分化过程。
2. **文献名称**：*Structural and Functional Analysis of CSRP2BP in TGF-β Signaling*
**作者**：Lee H, et al.
**摘要**：通过杆状病毒-昆虫细胞系统制备重组CSRP2BP蛋白，结合晶体结构解析和功能实验，揭示其作为TGF-β通路辅因子，通过结合Smad蛋白增强下游信号传导，促进纤维化相关疾病进展。
3. **文献名称**：*CSRP2BP Knockdown and Recombinant Protein Rescue in Cancer Metastasis Models*
**作者**：Wang L, et al.
**摘要**：利用重组人CSRP2BP蛋白进行功能回补实验，证明其通过调节上皮-间质转化(EMT)相关基因表达，抑制肿瘤细胞迁移和侵袭，提示其在癌症治疗中的潜在靶点价值。
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**注意**：上述内容为示例，若需真实文献，建议在PubMed、Google Scholar等平台以“CSRP2BP recombinant”或“CSRP2BP protein function”为关键词检索。
CSRP2BP (Cysteine and Glycine-Rich Protein 2 Binding Protein), also known as PDCD2 (Programmed Cell Death Protein 2), is a multifunctional nuclear protein involved in transcriptional regulation and cellular processes. It interacts with CSRP2. a protein implicated in cytoskeletal organization and differentiation, suggesting roles in modulating gene expression linked to cell proliferation, differentiation, and apoptosis. Structurally, CSRP2BP contains conserved domains, including a putative DNA-binding motif, enabling interactions with transcription factors or chromatin modifiers. Recombinant human CSRP2BP protein is typically produced via expression systems (e.g., E. coli or mammalian cells) for in vitro studies, retaining functional epitopes for antibody development, protein interaction assays, or mechanistic research. Studies highlight its involvement in embryogenesis, hematopoiesis, and tumorigenesis, with aberrant expression observed in cancers and immune disorders. Its precise molecular mechanisms remain under investigation, particularly its dual roles in promoting or suppressing apoptosis depending on cellular context. Recombinant CSRP2BP facilitates exploration of its regulatory networks, offering insights into therapeutic targeting for diseases involving dysregulated cell death or proliferation pathways.
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