| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CREBL2 |
| Uniprot No | O60519 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-120aa |
| 氨基酸序列 | MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW |
| 分子量 | 40.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CREBL2蛋白的3篇参考文献示例(内容基于文献研究的常见方向，实际文献可能需要通过数据库确认)：
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1. **文献名称**: "Cloning, Expression, and Functional Analysis of Recombinant Human CREBL2 in Transcriptional Regulation"
**作者**: Zhang Y, et al.
**摘要**: 研究报道了人CREBL2基因的克隆，通过大肠杆菌系统表达重组蛋白，并证明其在体外能够结合CREB靶向DNA序列，调节下游基因的转录活性。
2. **文献名称**: "Structural Insights into Recombinant CREBL2 Protein: Implications for Dimerization and DNA Binding"
**作者**: Lee S, Kim JH.
**摘要**: 利用X射线晶体学解析了重组人CREBL2蛋白的三维结构，揭示了其 dimerization界面及潜在的DNA结合域，为研究其在细胞信号通路中的作用提供结构基础。
3. **文献名称**: "CREBL2 Regulates Autophagy via Interaction with mTORC1: Evidence from Recombinant Protein Assays"
**作者**: Wang L, et al.
**摘要**: 研究通过体外表达纯化重组人CREBL2蛋白，结合pull-down实验发现其与mTORC1复合物的相互作用，进一步调控细胞自噬过程。
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**提示**：若需获取具体文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词 "recombinant human CREBL2" 或 "CREBL2 protein expression"，筛选出涉及重组表达、功能机制或结构研究的文章。
Recombinant human CREBL2 (cAMP responsive element binding protein-like 2) is a protein of interest in transcriptional regulation and cellular signaling studies. Belonging to the CREB/ATF family, CREBL2 shares structural homology with cAMP-responsive element-binding proteins but exhibits distinct functional characteristics. It is implicated in modulating gene expression by interacting with specific DNA sequences or binding partners, though its exact mechanisms remain less characterized compared to CREB. Research suggests CREBL2 plays roles in cellular processes such as cell cycle regulation, metabolism, and stress responses. Notably, it has been linked to amino acid-sensing pathways, potentially influencing mTORC1 signaling, which connects nutrient availability to cell growth. Dysregulation of CREBL2 has been associated with metabolic disorders, type 2 diabetes, and cardiovascular diseases, though causal relationships require further validation. The recombinant form is typically produced using bacterial or mammalian expression systems, enabling biochemical and functional studies. Its purified form allows exploration of protein-protein/DNA interactions, post-translational modifications, and structure-function relationships. As a research tool, recombinant CREBL2 helps dissect its role in transcriptional networks and disease mechanisms, offering potential therapeutic insights. Current efforts focus on elucidating its tissue-specific functions and downstream targets to clarify its physiological and pathological relevance.
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