| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CREBL1 |
| Uniprot No | Q99941 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-318aa |
| 氨基酸序列 | MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVSPSTTVLLQSLVQPPPGTEEGEKGRAWWLTPVIPALWEAEAGESPEVRSLRPAWPTW |
| 分子量 | 60.61 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CREBL1蛋白的示例性参考文献(虚构，仅供格式参考)：
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**文献名称**: *Structural characterization of recombinant human CREBL1 and its role in cAMP signaling pathways*
**作者**: Li, J., Wang, Y., & Chen, X.
**摘要**: 本研究通过表达和纯化重组人CREBL1蛋白，结合X射线晶体学解析其三维结构，揭示了其与cAMP响应元件(CRE)结合的独特结构域。实验表明，CREBL1可能通过调节CREB家族转录因子的活性，影响细胞增殖和凋亡相关基因的表达。
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**文献名称**: *CREBL1 modulates glucose homeostasis by interacting with hepatic insulin signaling pathways*
**作者**: Tanaka, M., et al.
**摘要**: 利用基因敲除小鼠模型，研究发现CREBL1缺失导致肝脏胰岛素信号通路(如PI3K/Akt)异常，进而引发糖代谢紊乱。重组CREBL1蛋白的体外实验证实其通过直接结合IRS-1增强胰岛素敏感性。
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**文献名称**: *Functional analysis of CREBL1 in ER stress-induced apoptosis*
**作者**: Kim, S., & Park, H.
**摘要**: 该文献报道了CREBL1在内质网应激中的双重作用：一方面通过激活CHOP促进凋亡，另一方面与ATF6形成复合物以缓解应激。重组蛋白的过表达实验显示其调控平衡可能与细胞类型相关。
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**文献名称**: *Recombinant CREBL1 as a potential biomarker in early-stage lung adenocarcinoma*
**作者**: Rodriguez, R., et al.
**摘要**: 通过ELISA检测临床样本，发现血清中CREBL1蛋白水平与肺腺癌分期呈负相关。重组蛋白的体外功能实验提示其可能通过抑制TGF-β通路抑制肿瘤迁移。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“recombinant human CREBL1”、“CREBL1 function”等获取最新研究进展。
CREBL1 (cAMP-responsive element-binding protein-like 1) is a member of the CREB/ATF transcription factor family, which plays critical roles in regulating cellular processes such as proliferation, differentiation, and stress responses. Structurally, it contains a leucine zipper motif that mediates dimerization and DNA binding. Unlike its well-studied homolog CREB1. CREBL1 lacks a canonical transcriptional activation domain, suggesting it may function as a modulator or competitive inhibitor in cAMP-mediated signaling pathways. Research indicates its involvement in metabolic regulation, with murine studies linking Crebl1 knockout to altered insulin signaling and glucose homeostasis.
Recombinant human CREBL1 protein is typically produced in *E. coli* or mammalian expression systems, enabling functional studies on its interactions with DNA elements (e.g., CRE sites) and partner proteins like other bZIP transcription factors. Its role in disease remains emerging, but associations with type 2 diabetes, obesity, and certain cancers have been proposed. Recent studies highlight its potential regulation of circadian rhythm genes and autophagy pathways. As an experimental tool, recombinant CREBL1 aids in elucidating transcriptional networks influenced by cAMP and cellular stress, offering insights into therapeutic targeting of metabolic disorders.
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