| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | COL24A1 |
| Uniprot No | Q17RW2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-957aa |
| 氨基酸序列 | MAHYITFLCMVLVLLLQNSVLAEDGEVRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFALDYLFAKSSRFLTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEESVCPTRIPVAARDERGFDILLGLDVNKKVKKRIQLSPKKIKGYEVTSKVDLSELTSNVFPEGLPPSYVFVSTQRFKVKKIWDLWRILTIDGRPQIAVTLNGVDKILLFTTTSVINGSQVVTFANPQVKTLFDEGWHQIRLLVTEQDVTLYIDDQQIENKPLHPVLGILINGQTQIGKYSGKEETVQFDVQKLRIYCDPEQNNRETACEIPGFNGECLNGPSDVGSTPAPCICPPGKPGLQGPKGDPGLPGNPGYPGQPGQDGKPGYQGIAGTPGVPGSPGIQGARGLPGYKGEPGRDGDKGDRGLPGFPGLHGMPGSKGEMGAKGDKGSPGFYGKKGAKGEKGNAGFPGLPGPAGEPGRHGKDGLMGSPGFKGEAGSPGAPGQDGTRGEPGIPGFPGNRGLMGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGEKGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLPGKDGDHGKPGIQGQPGPPGICDPSLCFSVIARRDPFRKGPNY |
| 分子量 | 99.3 KDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇模拟生成的关于重组人COL24A1蛋白的参考文献(非真实存在，仅供示例)：
1. **文献名称**：*Recombinant Human COL24A1: Expression and Role in Osteogenesis*
**作者**：Smith J. et al.
**摘要**：研究利用哺乳动物表达系统成功获得重组人COL24A1蛋白，并证明其通过调控TGF-β信号通路促进成骨细胞分化，揭示了该胶原蛋白在骨骼发育中的潜在作用。
2. **文献名称**：*Structural Characterization of COL24A1 and Its Interaction with Integrins*
**作者**：Lee H. et al.
**摘要**：通过圆二色谱和表面等离子共振技术解析重组COL24A1的三维结构，发现其C端结构域特异性结合整合素α2β1.提示其在细胞-基质黏附中的功能。
3. **文献名称**：*COL24A1 Overexpression in Tumor Stroma Correlates with Poor Prognosis*
**作者**：Zhang Y. et al.
**摘要**：通过制备重组COL24A1蛋白验证其在上皮性肿瘤间质中的高表达，并关联临床数据表明其表达水平与患者生存率负相关，可能作为癌症预后标志物。
⚠️ **注意**：以上文献及内容均为虚构，仅展示回答格式。实际研究中请通过PubMed、Web of Science等平台检索真实文献。
**Background of Recombinant Human COL24A1 Protein**
COL24A1 encodes the alpha-1 chain of type XXIV collagen, a member of the fibrillar collagen family. Unlike classical collagens (e.g., types I, II, III), type XXIV collagen is categorized as a "fibril-associated collagen with interrupted triple helices" (FACIT), characterized by periodic interruptions in its triple-helical glycine-X-Y repeat domains. COL24A1 is primarily expressed during embryonic development and tissue remodeling, with roles in regulating collagen fibrillogenesis, cell-matrix interactions, and tissue stability. It localizes to the extracellular matrix (ECM) of connective tissues, including bone, cartilage, and skin, where it modulates fibril organization and mechanical properties.
Recombinant COL24A1 protein is produced using expression systems (e.g., mammalian cells) to ensure proper post-translational modifications, such as hydroxylation of proline residues. This engineered protein enables functional studies, including ligand-receptor binding assays, ECM assembly analyses, and investigations into developmental disorders. Studies link COL24A1 mutations to skeletal abnormalities and connective tissue pathologies. Additionally, its expression is dysregulated in fibrosis and cancers, suggesting roles in disease progression. Research on recombinant COL24A1 advances understanding of collagen diversity and its implications in tissue engineering and regenerative medicine.
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