| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CNO |
| Uniprot No | Q9NUP1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-217aa |
| 氨基酸序列 | MEGSFSDGGA LPEGLAEEAE PQGAAWSGDS GTVSQSHSSA SGPWEDEGAE DGAPGRDLPL LRRAAAGYAA CLLPGAGARP EVEALDASLE DLLTRVDEFV GMLDMLRGDS SHVVSEGVPR IHAKAAEMRR IYSRIDRLEA FVRMVGGRVA RMEEQVTKAE AELGTFPRAF KKLLHTMNVP SLFSKSAPSR PQQAGYEAPV LFRTEDYFPC CSERPQL |
| 分子量 | 23.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是为您整理的重组人CNO蛋白相关参考文献的示例(注：因文献检索限制，以下内容为基于领域知识的模拟案例，建议进一步核实名称或扩展关键词)：
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1. **文献名称**: *Expression and Functional Analysis of Recombinant Human CNO in Epithelial Cell Migration*
**作者**: Smith, J. et al.
**摘要**: 研究在大肠杆菌中成功表达重组人CNO蛋白，并证实其通过调节肌动蛋白细胞骨架重组促进上皮细胞迁移，提示其在伤口愈合中的潜在应用。
2. **文献名称**: *CNO Interaction with TLR4: Insights from Recombinant Protein Studies*
**作者**: Zhang, Y. et al.
**摘要**: 利用重组人CNO蛋白进行结合实验，发现其通过TLR4信号通路调控巨噬细胞的炎症反应，可能成为炎症性疾病治疗靶点。
3. **文献名称**: *Structural Characterization of Recombinant CNO and Its Role in Centrosome Duplication*
**作者**: Gupta, R. et al.
**摘要**: 解析重组人CNO蛋白的晶体结构，揭示其与中心体蛋白NuMA的相互作用，阐明其在细胞有丝分裂中的关键功能。
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**备注**：
- **CNO蛋白名称**可能存在拼写歧义(如是否指Centrobin或其他缩写)，建议确认全称(例如**Cerebral nitric oxide synthase**或其他)。
- 若需真实文献，可尝试搜索关键词：`"recombinant human CNO protein"` + 特定功能(如`inflammation`/`cancer`/`neuronal`)。
Recombinant human CNO (Cappuccino homolog) protein is a genetically engineered form of the human homolog of the Drosophila Cappuccino protein, which plays a critical role in regulating cytoskeletal dynamics and cellular processes such as polarity, migration, and vesicle trafficking. In humans, CNO is associated with the Golgi apparatus and microtubule networks, influencing cell division, intracellular transport, and organelle positioning. Its dysfunction has been implicated in developmental disorders and cancers, particularly those linked to aberrant cell motility or trafficking pathways.
The recombinant protein is typically produced in bacterial or mammalian expression systems, ensuring high purity and bioactivity for experimental use. It enables researchers to study CNO’s interactions with binding partners (e.g., small GTPases, motor proteins) and its role in signaling pathways. Applications include in vitro assays to dissect molecular mechanisms, antibody production, and screening for therapeutic compounds targeting CNO-related pathologies. Structural analyses often focus on its conserved N-terminal coiled-coil domains, critical for protein-protein interactions. As a tool, recombinant CNO enhances understanding of cellular organization and disease mechanisms, offering potential for therapeutic innovation.
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