| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CKLFSF4 |
| Uniprot No | Q8IZR5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-234aa |
| 氨基酸序列 | MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA |
| 分子量 | 52.2 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3条关于重组人CKLFSF4蛋白的参考文献示例(注：文献为假设性内容，供参考)：
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1. **文献名称**：*"Expression and functional characterization of recombinant human CKLFSF4 in inflammatory regulation"*
**作者**：Li et al. (2020)
**摘要**：该研究通过哺乳动物表达系统(HEK293细胞)成功制备重组人CKLFSF4蛋白，并发现其通过激活NF-κB通路调控巨噬细胞的炎症因子分泌，提示其在免疫应答中的作用。
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2. **文献名称**：*"Structural insights into CKLFSF4 and its interaction with chemokine receptor CCR5"*
**作者**：Zhang et al. (2018)
**摘要**：作者利用大肠杆菌表达系统纯化重组CKLFSF4蛋白，结合X射线晶体学解析其三维结构，揭示其与CCR5受体的关键结合域，为靶向药物开发提供依据。
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3. **文献名称**：*"Recombinant CKLFSF4 suppresses tumor growth by modulating tumor-associated macrophages in a murine model"*
**作者**：Wang et al. (2021)
**摘要**：研究在小鼠模型中证明重组CKLFSF4蛋白可通过重编程肿瘤微环境中的巨噬细胞表型(M2向M1转化)，显著抑制乳腺癌进展。
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**注**：以上内容基于学术文献常见研究方向构造，实际文献需通过数据库(如PubMed、Web of Science)以关键词“CKLFSF4”“recombinant”检索获取。
Recombinant human CKLFSF4 (Chemokine-like Factor Superfamily Member 4) is a protein of interest in immune regulation and cellular communication research. Belonging to the CKLF family, which shares structural homology with chemokines and type I cytokine receptors, CKLFSF4 features conserved cysteine residues and a putative transmembrane domain. It is typically expressed as a secreted or membrane-bound protein, depending on alternative splicing, and is enriched in immune-related tissues like the thymus, spleen, and lymph nodes. Functionally, CKLFSF4 is implicated in modulating immune responses, including cell migration, adhesion, and proliferation. Studies suggest it interacts with extracellular matrix components or cell-surface receptors to influence signaling pathways, though its exact mechanisms remain under investigation. Dysregulation of CKLFSF4 has been linked to pathological conditions such as cancer progression, inflammatory diseases, and autoimmune disorders, highlighting its potential as a therapeutic target or diagnostic biomarker. Recombinant CKLFSF4. produced via engineered expression systems (e.g., E. coli or mammalian cells), enables functional studies, antibody development, and exploration of its role in disease pathways. Ongoing research aims to clarify its physiological ligands and signaling networks, bridging gaps in understanding its contributions to immune homeostasis and disease pathogenesis.
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