关键信息
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基因名
STEAP4
- 应用
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别名
STEAP4；STAMP2；Metalloreductase STEAP4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q687X5
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表达区间
1-152aa
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氨基酸序列
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEKT CIDALPLTMN SSEKQETVCI FGTGDFGRSL GLKMLQCGYS VVFGSRNPQKTTLLPSGAEV LSYSEAAKKS GIIIIAIHRE HYDFLTELTE VLNGKILVDI SNNLKINQYP ESNAEYLAHL VPGAHVVKAF NTISAWALQS GALDASRQ
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
STEAP4, also known as six-transmembrane epithelial antigen of the prostate 4, is a member of the STEAP family of proteins, which are implicated in various physiological and pathological processes, particularly in cancer and metabolism. Initially identified as a protein overexpressed in prostate cancer, STEAP4 has garnered interest due to its potential roles in cellular iron metabolism and lipid storage. Studies suggest that STEAP4 may function as a metalloreductase, facilitating the reduction of ferric iron to ferrous iron, which is crucial for cellular iron uptake. Additionally, it is also believed to play a role in adipogenesis and inflammation, thus linking it to metabolic disorders such as obesity and diabetes. Research into STEAP4 has expanded beyond cancer, exploring its implications in conditions such as cardiovascular diseases and neurodegenerative disorders. Given the growing recognition of the protein's multifaceted roles, the recombinant expression of STEAP4 has become a pivotal area of study, with the aim of characterizing its function and developing potential therapeutic strategies. Understanding the molecular mechanisms underlying STEAP4's actions can contribute to the advancement of targeted therapies, making it a significant focus within the field of biomedicine and metabolic research.
