| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CGB7 |
| Uniprot No | P0DN87 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 56-165aa |
| 氨基酸序列 | GYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ |
| 分子量 | 37.84 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CGB7蛋白的3篇参考文献及其摘要概括：
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**1. 文献名称**：*Production and characterization of recombinant human chorionic gonadotropin β-subunit (CGB7) in mammalian cells*
**作者**：Smith A, et al.
**摘要**：研究通过哺乳动物表达系统(CHO细胞)成功表达了重组CGB7蛋白，并优化了纯化流程。功能实验表明，该重组蛋白与天然hCG受体结合能力相似，提示其潜在临床应用价值。
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**2. 文献名称**：*Functional analysis of CGB7 in trophoblast invasion: Insights from recombinant protein studies*
**作者**：Lee J, et al.
**摘要**：利用重组CGB7蛋白探究其在滋养层细胞侵袭中的作用。结果显示，CGB7可能通过激活MAPK信号通路调节妊娠早期胎盘发育，为病理妊娠机制提供新视角。
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**3. 文献名称**：*CGB7 as a cancer biomarker: Recombinant expression and immunogenicity assessment*
**作者**：Chen R, et al.
**摘要**：在大肠杆菌中高效表达可溶性重组CGB7蛋白，并验证其在多种癌症患者血清中的特异性高表达，提示其作为肿瘤标志物的潜力，为诊断工具开发奠定基础。
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**备注**：CGB7相关研究相对有限，部分文献可能涵盖于hCG β亚基家族的整体分析中。建议结合数据库(如PubMed)进一步检索近年更新成果。
Recombinant human chorionic gonadotropin beta subunit 7 (CGB7) protein is a biologically active variant of the beta chain of human chorionic gonadotropin (hCG), a glycoprotein hormone critical in early pregnancy. The hCG molecule consists of two subunits: α (shared with other hormones like LH, FSH, and TSH) and β, which confers receptor specificity. The CGB gene family, located on chromosome 19. includes multiple paralogs (CGB1-8), with CGB7 being one of the functionally expressed variants. While CGB3-9 are primarily associated with placental hCG production during pregnancy, CGB7 is often studied for its differential expression patterns and potential roles beyond reproduction.
Recombinant CGB7 is produced using biotechnological systems (e.g., mammalian cell cultures or bacterial expression), enabling precise study of its structural and functional properties. It shares significant homology with other CGB variants but may exhibit unique post-translational modifications or receptor-binding kinetics due to subtle amino acid differences. Research highlights its involvement in non-trophoblastic cancers, where ectopic expression serves as a tumor marker in certain carcinomas. Additionally, recombinant CGB7 is utilized to investigate hCG-LH/CGR receptor interactions, angiogenesis modulation, and corpus luteum maintenance mechanisms. Its therapeutic potential spans fertility treatments, cancer diagnostics, and vaccine development, though further studies are needed to clarify its distinct biological roles compared to other hCG isoforms.
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