| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDH9 |
| Uniprot No | Q9ULB4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-789aa |
| 氨基酸序列 | MRTYHYIPLFIWTYMFHTVDTILLQEKPNSYLSSKKIAGLTKDDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLADMYGGDDSDRD |
| 分子量 | 88.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人钙粘蛋白-9(CDH9)的示例参考文献(注：以下内容为模拟生成，具体文献需通过学术数据库查询获取)：
1. **文献名称**：*CDH9 gene variants and their association with neurodevelopmental disorders*
**作者**：Smith A, et al.
**摘要**：研究探讨了CDH9基因多态性与自闭症谱系障碍(ASD)的关联，发现CDH9在神经突触形成中的作用异常可能与ASD发病机制相关。
2. **文献名称**：*Cadherin-9 regulates glioma cell migration via Rho GTPase signaling*
**作者**：Lee J, et al.
**摘要**：通过体外实验证明CDH9在胶质瘤细胞中高表达，并通过调控RhoA信号通路抑制肿瘤细胞迁移和侵袭。
3. **文献名称**：*CDH9 expression correlates with hepatocellular carcinoma progression*
**作者**：Wang Y, et al.
**摘要**：临床分析显示，CDH9在肝细胞癌组织中的表达显著下调，其低表达与患者预后不良及肿瘤转移相关。
4. **文献名称**：*Structural insights into the homophilic adhesion mechanism of CDH9*
**作者**：Zhang X, et al.
**摘要**：利用冷冻电镜解析CDH9胞外结构域的三维构象，揭示其介导同源细胞黏附的分子机制，为靶向干预提供理论基础。
**建议**：可通过PubMed、Google Scholar或Web of Science检索关键词“CDH9”或“Cadherin-9”获取具体文献。研究领域多集中于神经发育、肿瘤生物学和结构生物学。
Cadherin-9 (CDH9), a member of the classical cadherin superfamily, is a calcium-dependent cell adhesion protein crucial for mediating intercellular interactions. Encoded by the CDH9 gene on human chromosome 16q24. it features a conserved structure: extracellular cadherin (EC) repeats for homophilic binding, a transmembrane domain, and cytoplasmic catenin-binding regions that regulate cytoskeletal dynamics. CDH9 is predominantly expressed in the nervous system, particularly during brain development, where it facilitates synaptic specificity, neurite outgrowth, and neural circuit formation. Studies link CDH9 dysregulation to neurodevelopmental disorders; genome-wide associations implicate its loci in autism spectrum disorder (ASD) susceptibility.
Beyond neurology, CDH9 exhibits tissue-specific roles. In cancer, it displays dual roles—acting as a tumor suppressor in gliomas by inhibiting migration, yet promoting aggression in hepatocellular carcinoma. Recombinant CDH9. produced via mammalian or bacterial systems, enables functional studies to dissect adhesion mechanisms, signaling pathways, and disease-related mutations. Its application in vitro models aids in exploring therapeutic strategies targeting cell adhesion defects. Despite progress, CDH9's pleiotropic functions and regulatory networks remain under investigation, highlighting its potential as a biomarker or intervention target in neurological and oncological contexts.
×
