| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDH11 |
| Uniprot No | P55287 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 54-617aa |
| 氨基酸序列 | GWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLST |
| 分子量 | 67.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CDH11蛋白的3篇代表性文献概览(内容为模拟生成，非真实文献)：
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1. **文献名称**: *CDH11 promotes osteoblastic differentiation and bone development through Wnt/β-catenin signaling*
**作者**: Li Y, et al.
**摘要**: 研究利用重组CDH11蛋白，揭示了其在间充质干细胞向成骨细胞分化中的关键作用。实验表明CDH11通过激活Wnt/β-catenin信号通路增强骨形成，为骨质疏松症治疗提供潜在靶点。
2. **文献名称**: *CDH11-mediated cell adhesion drives breast cancer metastasis to bone*
**作者**: Jones R, et al.
**摘要**: 通过体外重组CDH11蛋白实验，证明其通过增强肿瘤细胞与骨基质细胞的粘附，促进乳腺癌骨转移。抑制CDH11可显著降低小鼠模型中骨转移灶的形成。
3. **文献名称**: *Recombinant CDH11 extracellular domain attenuates inflammatory arthritis in mice*
**作者**: Chen L, et al.
**摘要**: 研究利用重组CDH11胞外段蛋白，发现其可通过竞争性阻断CDH11介导的滑膜细胞异常粘附，缓解小鼠类风湿性关节炎模型的炎症和关节损伤。
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提示：实际文献查询建议通过PubMed或Google Scholar使用关键词(如“recombinant CDH11 protein”“CDH11 function”)检索近年高被引论文。
CDH11. a member of the classical cadherin superfamily, is a calcium-dependent transmembrane glycoprotein critical for mediating cell-cell adhesion and tissue morphogenesis. It shares the conserved cadherin-repeat extracellular domains for homophilic binding and a cytoplasmic domain that interacts with β-catenin/p120-catenin to regulate cytoskeletal dynamics and signaling. Unlike epithelial cadherins (e.g., E-cadherin), CDH11 is predominantly expressed in mesenchymal cells, osteoblasts, synovial fibroblasts, and cancer-associated fibroblasts, playing specialized roles in osteogenesis, neural crest migration, and mechanotransduction.
Recombinant human CDH11 is typically produced in mammalian or insect expression systems to ensure proper post-translational modifications. Its dysregulation is implicated in pathological processes: upregulated CDH11 promotes cancer invasion/metastasis in bone-trophic cancers (e.g., prostate, breast) by enhancing stromal interactions, while its loss correlates with skeletal malformations (cleidocranial dysplasia) and fibrosis. In chronic inflammation, synovial CDH11 drives rheumatoid arthritis progression through fibroblast invasiveness. Therapeutic targeting of CDH11 using antibodies or inhibitors is under exploration for osteoarticular diseases and metastatic cancers. Structural studies of recombinant CDH11 help map functional epitopes and design modulators of cadherin-mediated adhesion signaling.
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