首页 / 产品 / 蛋白 / 其他蛋白

Recombinant Human CDC42EP3 Protein

  • 中文名: 重组人Cdc42效应蛋白3(CDC42EP3)
  • 别    名: CDC42EP3; BORG2; CEP3Cdc42 effector Protein 3; Binder of Rho GTPases 2; MSE55-related Cdc42-binding Protein
货号: PA2000-6589
Price: ¥询价
数量:
大包装询价

产品详情

纯度>90%SDS-PAGE.
种属Human
靶点CDC42EP3
Uniprot NoQ9UKI2
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-254aa
氨基酸序列MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQGNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALMLPLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQSSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK
分子量53.68 kDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下是关于重组人Cdc42效应蛋白3(CDC42EP3)的3篇代表性文献及其摘要简述:

1. **文献名称**:**"Cdc42 effector protein 3 (CDC42EP3) regulates septin dynamics and inflammation-related articular cartilage degeneration"**

**作者**:Yamaguchi et al.

**摘要**:研究发现CDC42EP3通过结合Septin蛋白并调节其纤维结构组装,参与炎症相关的软骨退变过程,可能成为骨关节炎等疾病的潜在治疗靶点。

2. **文献名称**:**"CDC42EP3/BORG2 modulates cell-cell adhesion by interacting with Septin and regulating actin cytoskeleton"**

**作者**:Snyder et al.

**摘要**:该研究揭示了CDC42EP3通过调控Septin蛋白网络和肌动蛋白骨架重组,影响上皮细胞的黏附与极性,为理解细胞形态维持和迁移机制提供了新视角。

3. **文献名称**:**"CDC42EP3 promotes tumor progression by regulating cell proliferation and invasion in colorectal cancer"**

**作者**:Jansen et al.

**摘要**:实验证明CDC42EP3在结直肠癌组织中显著高表达,通过激活RhoA/ROCK信号通路增强癌细胞增殖和侵袭能力,提示其可能作为癌症治疗的分子靶点。

(注:以上文献信息为模拟示例,实际研究需通过PubMed或专业数据库检索确认。)


背景信息

CDC42 effector protein 3 (CDC42EP3), also known as BORG2. is a member of the CDC42EP/BORG family of proteins that interact with the small GTPase CDC42. a critical regulator of cytoskeletal dynamics and cell polarity. These scaffold proteins modulate actin polymerization, septin organization, and cell-cell junction formation by serving as adaptors between CDC42 and downstream effectors. Structurally, CDC42EP3 contains a central CDC42-binding domain (CRIB) and multiple coiled-coil regions that mediate protein-protein interactions.

Functionally, CDC42EP3 is implicated in coordinating cytoskeletal remodeling during processes like cell migration, morphogenesis, and tissue development. It interacts with septins, filamentous GTP-binding proteins, to stabilize membrane-associated complexes and regulate extracellular matrix remodeling. Studies also link CDC42EP3 to inflammatory responses, as it influences TNF-α signaling and neutrophil adhesion.

Dysregulation of CDC42EP3 has been observed in pathological contexts. Elevated expression correlates with tumor progression in certain cancers, where it may enhance invasiveness by disrupting cell-cell junctions and promoting epithelial-mesenchymal transition. Conversely, its suppression in vascular endothelial cells has been associated with impaired angiogenesis. While its dual roles in cancer (tumor-suppressive vs. pro-metastatic) remain context-dependent, CDC42EP3 is increasingly studied as a potential therapeutic target or biomarker for inflammatory diseases and malignancies. Ongoing research aims to clarify its tissue-specific signaling networks and pathological contributions.


客户数据及评论

折叠内容

大包装询价

×