| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CD302 |
| Uniprot No | Q8IX05 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-232aa |
| 氨基酸序列 | MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASFKWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNHILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD |
| 分子量 | 26.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CD302抗原蛋白的3篇参考文献及简要摘要：
1. **文献名称**：*Characterization of recombinant human CD302 reveals its role in phagocytosis and immune regulation*
**作者**：Li Y, et al.
**摘要**：研究通过表达重组人CD302蛋白，发现其与巨噬细胞表面受体结合后可增强病原体的吞噬能力，并参与TLR信号通路的调控，提示其在先天免疫中的潜在作用。
2. **文献名称**：*Structural and functional analysis of CD302 in dendritic cell maturation*
**作者**：Wang X, et al.
**摘要**：利用重组CD302蛋白解析其晶体结构，表明其C端凝集素结构域介导了与糖类的结合，并通过激活NF-κB通路促进树突状细胞成熟，为免疫治疗提供新靶点。
3. **文献名称**：*Recombinant CD302 as a biomarker for inflammatory bowel disease*
**作者**：Zhang L, et al.
**摘要**：通过检测患者血清中重组CD302蛋白结合活性，发现其表达水平与克罗恩病活动度显著相关，提示其作为炎症性肠病诊断标志物的潜力。
注：以上文献为根据CD302已知功能的模拟示例，实际引用时需通过PubMed或Web of Science检索具体文献。
CD302. also known as CLEC13A or DLEC, is a transmembrane protein belonging to the C-type lectin receptor family, characterized by a conserved carbohydrate-recognition domain (CRD) in its extracellular region. Primarily expressed on myeloid cells, including dendritic cells, macrophages, and neutrophils, it plays roles in immune modulation, pathogen recognition, and homeostasis. CD302 interacts with endogenous ligands (e.g., glycoproteins on apoptotic cells) and exogenous pathogens, facilitating phagocytosis, immune cell adhesion, and signal transduction. Its dual functionality in promoting pathogen clearance while regulating inflammatory responses has garnered research interest. Aberrant CD302 expression is linked to diseases like cancer and autoimmune disorders, suggesting therapeutic potential. Recombinant human CD302 antigen protein, typically produced via mammalian or bacterial expression systems, retains the CRD's structural and functional integrity. This recombinant tool is pivotal for studying ligand interactions, immune pathway mechanisms, and diagnostics/therapeutics development. Ongoing research aims to clarify its role in immune surveillance and tolerance, as well as its paradoxical effects in tumor progression or suppression. The protein's conserved sequence across species underscores its biological significance.
×
