| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCT6B |
| Uniprot No | Q92526 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-530aa |
| 氨基酸序列 | MAAIKAVNSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLASGAGDIKLTKDGNVLLDEMQIQHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEVLEEVKVTKEMKRKILLDVARTSLQTKVHAELADVLTEVVVDSVLAVRRPGYPIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLAKHGIVALRRAKRRNMERLSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFTFIEECVNPCSVTLLVKGPNKHTLTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQAFADALLIIPKVLAQNAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLK |
| 分子量 | 84.04 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人CCT6B蛋白的3篇代表性文献摘要示例(请注意为虚拟示例，实际文献请查询学术数据库)：
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1. **文献名称**: "CCT6B mediates the folding of β-tubulin via the TRiC complex"
**作者**: Smith A, et al. (2020)
**摘要**: 研究揭示了CCT6B作为TRiC分子伴侣亚基在微管蛋白β亚基折叠中的关键作用，证明其缺失导致细胞周期阻滞和微管网络异常。
2. **文献名称**: "Overexpression of CCT6B in hepatocellular carcinoma promotes tumor metastasis"
**作者**: Zhang Y, et al. (2018)
**摘要**: 发现CCT6B在肝癌组织中高表达，通过调控HIF-1α通路增强肿瘤细胞侵袭和转移能力，提示其作为潜在治疗靶点。
3. **文献名称**: "Structural insights into CCT6B subunit architecture in the human TRiC chaperonin"
**作者**: Lee J, et al. (2021)
**摘要**: 利用冷冻电镜解析CCT6B在TRiC复合体中的三维结构，阐明其与客户蛋白的互作界面及ATP水解调控机制。
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建议通过 **PubMed** 或 **Google Scholar** 以“CCT6B”、“TCP-1 zeta-2”、“TRiC chaperonin”等关键词检索最新文献，关注其在蛋白质折叠、癌症及神经系统疾病中的研究进展。
Chaperonin-containing TCP-1 subunit zeta-2 (CCT6B) is a key component of the CCT/TRiC complex, a conserved molecular chaperone critical for folding cytoskeletal proteins like actin and tubulin. This hetero-oligomeric complex comprises two stacked rings, each containing eight distinct subunits (CCT1–8). CCT6B, the zeta-2 isoform of subunit 6. diverges from its paralog CCT6A in tissue expression, showing enrichment in testis, brain, and specific cancers. Beyond facilitating ATP-dependent protein folding, CCT6B interacts with cyclin E, linking it to cell cycle regulation and proliferation. Dysregulation of CCT6B is implicated in neurodegenerative diseases (e.g., Alzheimer’s) through aggregation-prone protein accumulation, and in cancers via enhanced tumor growth and metastasis. Mutations in CCT6B are associated with rare neurodevelopmental disorders, underscoring its role in neuronal health. Additionally, CCT6B may contribute to viral replication by assisting viral protein assembly. Its dual functions in homeostasis and disease, coupled with tissue-specific expression, position CCT6B as a potential biomarker or therapeutic target. Ongoing research explores its mechanistic nuances and relevance in proteinopathies and oncology, highlighting its broad impact on cellular and pathological processes.
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