| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCPG1 |
| Uniprot No | Q9ULG6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-757aa |
| 氨基酸序列 | MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHFKEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQIIQRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDGVFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL |
| 分子量 | 87.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人细胞周期进程蛋白1(CCPG1)的参考文献概述：
1. **文献名称**：*"CCPG1 regulates cell cycle progression by interacting with CDK2 in human hepatocellular carcinoma"*
**作者**：Li X, Wang Y, et al.
**摘要**：该研究通过重组人CCPG1蛋白实验发现，CCPG1通过与CDK2直接结合促进肝细胞癌细胞G1/S期转换，并揭示其过表达与患者不良预后相关。
2. **文献名称**：*"Recombinant CCPG1 modulates Wnt/β-catenin signaling to inhibit colorectal cancer metastasis"*
**作者**：Zhang R, Chen L, et al.
**摘要**：研究利用重组CCPG1证明其在结直肠癌中通过抑制Wnt通路降低β-catenin活性，从而延缓细胞周期并抑制肿瘤转移。
3. **文献名称**：*"CCPG1 is a novel regulator of DNA damage checkpoint via stabilizing p21 in breast epithelial cells"*
**作者**：Gupta S, Patel A, et al.
**摘要**：研究发现重组CCPG1通过与p21相互作用，增强其稳定性以响应DNA损伤，延迟细胞周期进程并促进修复，提示其在基因组稳定性中的作用。
4. **文献名称**：*"Functional characterization of recombinant CCPG1 in pancreatic cancer: A tumor suppressor role through cell cycle arrest"*
**作者**：Kim H, Nguyen T, et al.
**摘要**：通过体外重组实验证实，CCPG1过表达诱导胰腺癌细胞G2/M期阻滞，下调Cyclin B1.抑制增殖并促进凋亡，支持其作为抑癌因子的功能。
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注：上述文献信息为示例性概括，实际引用请根据真实论文调整。若需具体文献，建议在PubMed或Web of Science中检索关键词“CCPG1 recombinant”或“CCPG1 cell cycle”。
**Background of Recombinant Human Cell Cycle Progression Protein 1 (CCPG1)**
CCPG1. also known as Cell Cycle Progression Protein 1. is a regulatory protein implicated in controlling cell cycle transitions, particularly the G1/S phase checkpoint. It is encoded by the *CCPG1* gene and is hypothesized to interact with cyclin-dependent kinases (CDKs) or other checkpoint proteins to modulate cell cycle progression. Studies suggest CCPG1 may act as a tumor suppressor, as its dysregulation or loss of expression has been observed in certain cancers, correlating with uncontrolled proliferation and poor prognosis.
Structurally, CCPG1 contains conserved domains that facilitate protein-protein interactions, potentially linking it to DNA damage response pathways or transcriptional regulation. Its expression is tightly regulated during cell cycle phases, often suppressed by epigenetic modifications (e.g., promoter hypermethylation) in malignancies.
Recombinant human CCPG1. produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), enables functional studies to dissect its role in cell cycle control, apoptosis, and oncogenesis. Current research focuses on its interaction networks, therapeutic potential as a biomarker for cancer diagnosis, or as a target for restoring cell cycle checkpoints in tumor cells. Further investigations are needed to fully elucidate its molecular mechanisms and clinical relevance.
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