| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC96 |
| Uniprot No | Q2M329 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-555aa |
| 氨基酸序列 | MDVSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPKPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVRQKIREAKAFLPS |
| 分子量 | 61.1 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC96的3-4篇文献概述(注：文献为虚构示例，实际研究中可能存在差异)：
1. **《CCDC96 promotes lung adenocarcinoma progression via ERK signaling pathway》**
作者：Chen Y. et al., 2020(*Oncol Rep*)
摘要：研究发现CCDC96在肺腺癌组织中高表达，通过激活ERK信号通路促进肿瘤细胞增殖和迁移，提示其可能作为肺腺癌的预后标志物。
2. **《CCDC96 regulates cardiac development through modulating myocardial differentiation》**
作者：Zhang J. et al., 2022(*Cell Mol Life Sci*)
摘要：在小鼠模型中，CCDC96缺失导致心脏发育异常，其通过调控心肌细胞分化相关基因(如GATA4)影响胚胎期心脏形态形成。
3. **《Loss of CCDC96 disrupts spermatogenesis in mice》**
作者：Wang L. et al., 2019(*Development*)
摘要：首次发现CCDC96特异性表达于睾丸组织，通过维持精子细胞顶体结构完整性参与精子发生，基因敲除导致雄性小鼠不育。
4. **《CCDC96 interacts with cyclin-dependent kinases to regulate cell cycle progression》**
作者：Gupta M. et al., 2021(*J Biol Chem*)
摘要：蛋白质互作分析显示，CCDC96与CDK2/4结合并调控G1/S期转换，提示其在细胞周期调控中发挥未知功能。
(注：以上内容为模拟文献，实际研究需通过PubMed等数据库查询CCDC96相关论文。)
Coiled-coil domain-containing protein 96 (CCDC96) is a human protein encoded by the *CCDC96* gene, located on chromosome 17q21.2. It belongs to the family of coiled-coil domain-containing proteins, characterized by structural motifs that facilitate protein-protein interactions. CCDC96 is widely expressed in various tissues, with higher levels observed in the testis, lungs, and immune cells. Though its precise molecular function remains under investigation, studies suggest involvement in cellular processes such as mitotic regulation, DNA damage response, and inflammatory signaling.
CCDC96 has been linked to immune modulation, potentially interacting with components of the NF-κB pathway to influence cytokine production. Emerging evidence associates *CCDC96* dysregulation with pathological conditions, including cancers (e.g., lung adenocarcinoma, hepatocellular carcinoma) and inflammatory disorders. Aberrant expression patterns correlate with tumor progression and immune infiltration, hinting at its dual role as a biomarker or therapeutic target. Functional studies using knockdown models reveal impacts on cell proliferation, apoptosis, and metastasis, though mechanistic details require further validation.
Research on CCDC96 remains in early stages, with ongoing efforts to clarify its structural interactions, regulatory networks, and therapeutic potential in disease contexts. Advances in proteomics and CRISPR-based screening may accelerate its functional characterization.
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