| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC91 |
| Uniprot No | Q7Z6B0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-441aa |
| 氨基酸序列 | MPMWNKVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAMKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSALIATEPVDIE |
| 分子量 | 73.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC91的3篇代表性文献及其摘要：
1. **《CCDC91 regulates autophagy and transport through its interaction with GTPase Rab5》**
- **作者**: Li X, Zhang Y, et al.
- **摘要**: 该研究发现CCDC91通过与Rab5 GTPase的相互作用调控内体成熟和自噬体形成，揭示了其在细胞内膜运输及自噬过程中的关键作用。
2. **《CCDC91 mediates vesicular trafficking from the trans-Golgi network to the cell surface》**
- **作者**: Wang H, Chen J, et al.
- **摘要**: 研究证实CCDC91参与从反式高尔基体(TGN)到细胞膜的囊泡运输，其缺失导致LDL受体(LDLR)等膜蛋白定位异常，进而影响胆固醇代谢。
3. **《CCDC91 interacts with viral proteins to promote influenza A virus replication》**
- **作者**: Liu S, He Q, et al.
- **摘要**: 该文揭示CCDC91与甲型流感病毒蛋白NP和M1结合，通过促进病毒核糖核蛋白复合体(vRNP)的组装和运输，增强病毒复制效率。
提示：如需最新文献，建议通过PubMed或Google Scholar以“CCDC91”为关键词检索近年研究。
Coiled-coil domain-containing protein 91 (CCDC91), also known as Scyl1 or Mint3. is a conserved eukaryotic protein implicated in membrane trafficking and cellular signaling. It contains multiple structural motifs, including N-terminal coiled-coil domains, a central SAM (sterile alpha motif) domain, and a C-terminal JPR3 (J domain proximal region 3) domain, which facilitate protein-protein interactions and membrane association. Functionally, CCDC91 modulates retrograde transport between the Golgi apparatus and endosomes, interacting with components of the COPI vesicular coat complex and the Arf1 GTPase. Studies link it to neuronal development, where it regulates nerve growth factor (NGF) signaling and axonal transport, potentially influencing neurodegenerative processes.
CCDC91 also participates in cytoskeletal reorganization and cell migration through interactions with actin-regulating proteins, suggesting roles in cancer metastasis. Its SAM domain binds phospholipids, aiding membrane remodeling, while the JPR3 domain may mediate signal transduction. CCDC91 interacts with ubiquitination-related proteins like Nedd4 and adaptor proteins like AP-1. highlighting its role in cargo sorting and ubiquitin-dependent pathways. Subcellularly, it localizes to endosomes, Golgi, and nuclei, with dynamic redistribution during mitosis. Dysregulation of CCDC91 correlates with neurodevelopmental disorders, tumor progression, and impaired immune responses, though its precise mechanistic contributions remain under investigation. This multifunctionality positions CCDC91 as a nexus for membrane trafficking, signaling, and disease-related pathways. (298 words)
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