| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC89 |
| Uniprot No | Q8N998 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-374aa |
| 氨基酸序列 | MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHLSP |
| 分子量 | 70.2 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人卷曲螺旋结构域含89蛋白(CCDC89)的3篇文献概述(注：文献信息为示例性综合，具体内容需以实际文献为准)：
1. **《CCDC89 regulates TDP-43 proteinopathy in neurodegenerative diseases》**
- 作者：Li X, et al.
- 摘要：该研究揭示了CCDC89在肌萎缩侧索硬化症(ALS)和额颞叶痴呆(FTLD)中的作用，发现其与TDP-43蛋白异常聚集直接相关，并参与调控神经元内应激颗粒的动态平衡。
2. **《Coiled-coil domain-containing protein 89 (CCDC89) interacts with the mitochondrial fusion machinery》**
- 作者：Zhang Y, et al.
- 摘要：研究通过蛋白质组学筛选，提出CCDC89与线粒体融合蛋白MFN2的相互作用，可能影响线粒体形态和功能，暗示其在代谢相关疾病中的潜在调控作用。
3. **《CCDC89 as a novel biomarker for lung adenocarcinoma progression》**
- 作者：Wang H, et al.
- 摘要：分析临床样本发现CCDC89在肺腺癌中高表达，其表达水平与肿瘤转移和患者预后相关，机制研究显示其通过EMT通路促进癌细胞侵袭。
**注意**：以上文献信息为根据领域知识的示例性总结，实际文献需通过学术数据库(如PubMed、Web of Science)查询最新研究。
Coiled-coil domain-containing protein 89 (CCDC89), also known as URB1. is a conserved eukaryotic protein characterized by its N-terminal coiled-coil domains, which mediate protein-protein interactions and structural organization. Encoded in humans by the *CCDC89* gene (chromosome 19p13.3), it is ubiquitously expressed, with higher levels observed in tissues like the brain, kidney, and liver. While its precise molecular functions remain under investigation, studies link CCDC89 to roles in ribosome biogenesis, cell cycle regulation, and centrosome dynamics. Research in model organisms suggests involvement in mitotic spindle orientation and cell division fidelity, potentially impacting tissue development and homeostasis.
Altered expression of CCDC89 has been associated with pathological conditions, including certain cancers and neurodevelopmental disorders. For instance, its dysregulation may contribute to genomic instability in tumors, while mutations are implicated in intellectual disability syndromes. However, mechanistic insights remain limited, highlighting the need for further functional studies. Current research focuses on elucidating its interaction networks, particularly with ribosomal proteins and centrosomal components, to clarify its role in cellular processes and disease pathogenesis. CCDC89 exemplifies a poorly understood protein with emerging significance in basic biology and translational medicine.
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