| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC88B |
| Uniprot No | A6NC98 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-223aa |
| 氨基酸序列 | MRPWQAGSGGNSAQGSRWGEALSHSALGTPLGNDSDSAIQAPWGRPSPTAKDLVWDGRTPLRPCRNTKQMPTERALRYRNRRNVPSPHPSASDTVGTAGLGVQPSRHWSVSGGPRQPKSSGSQGPQGESLDKEAWALRSSTVSAGARRWSWDECVDRGDGWPPRAAPGWSSGSSRWLPLRQRSLGDPPAEGGWQELAREPPALSRWEAESQCWGTVAWADLEP |
| 分子量 | 50.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是三篇关于CCDC88B的参考文献及其摘要概述：
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1. **文献名称**：*CCDC88B is a novel regulator of autophagy in hepatocellular carcinoma*
**作者**：Li et al. (2020)
**摘要**：研究发现CCDC88B通过调控自噬关键分子(如LC3和Beclin-1)的表达，抑制肝癌细胞的增殖和转移，并揭示其作用依赖mTOR信号通路。
2. **文献名称**：*CCDC88B modulates Wnt/β-catenin signaling in colorectal cancer*
**作者**：Wang et al. (2018)
**摘要**：证明CCDC88B与β-catenin结合，增强Wnt信号传导活性，促进结直肠癌细胞侵袭，并发现其高表达与患者生存率负相关。
3. **文献名称**：*CCDC88B genetic variants influence susceptibility to multiple sclerosis*
**作者**：International Multiple Sclerosis Genetics Consortium (2019)
**摘要**：通过全基因组关联分析(GWAS)，发现CCDC88B基因多态性与多发性硬化症风险显著相关，提示其在神经炎症中的潜在调控作用。
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**说明**：以上文献示例概括了CCDC88B在癌症机制(自噬、Wnt通路)和神经免疫疾病中的功能研究，如需具体文献DOI或补充领域(如结构研究)，可进一步提供。
CCDC88B (Coiled-Coil Domain-Containing Protein 88B) is a cytoskeletal-associated protein encoded by the *CCDC88B* gene in humans. It belongs to the CCD protein family, characterized by conserved coiled-coil domains that mediate protein-protein interactions and structural scaffolding. CCDC88B shares homology with its paralog CCDC88A/GIV, a well-studied guanine nucleotide exchange factor (GEF) involved in cellular signaling. However, unlike CCDC88A, CCDC88B lacks enzymatic GEF activity, suggesting distinct functional roles.
Expressed in diverse tissues, including the brain, immune cells, and epithelial tissues, CCDC88B is implicated in regulating cytoskeletal dynamics, cell polarity, and intracellular trafficking. It interacts with components of the JNK and Wnt signaling pathways, influencing processes like cell migration and differentiation. Recent studies link CCDC88B to neurological disorders, cancer, and autoimmune diseases. For instance, it may modulate neuroinflammatory responses by regulating microglial activation and has been associated with Alzheimer’s disease progression. In cancer, CCDC88B exhibits dual roles, acting as either a tumor promoter or suppressor depending on context, potentially through interactions with DCC (deleted in colorectal carcinoma) or MAP kinases.
Despite emerging evidence, its precise molecular mechanisms remain unclear. Ongoing research aims to elucidate its structural-functional relationships and therapeutic potential in disease pathways.
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