| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC85A |
| Uniprot No | Q96PX6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-553aa |
| 氨基酸序列 | MSKAAGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRGLKDINQKLQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAGCAGSRCSIDSQASLCQLTASTAPYVRDVGDGSSTSSTGSTDSPDHHKHHASSGSPEHLQKPRSEGSPEHSKHRSASPEHPQKPRACGTPDRPKALKGPSPEHHKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPEHARHSGGSPEHLQKHALGGSLEHLPRARGTSPEHLKQHYGGSPDHKHGGGSGGSGGSGGGSREGTLRRQAQEDGSPHHRNVYSGMNESTLSYVRQLEARVRQLEEENRMLPQASQNRRQPPTRNSSNMEKGWGSRARRVLQWWQGCRGIGRCLPTLPGSFRLSSGADGSNSSPNSAASFSGHATPSQQPEPVVHSLKVVWRKLGDAAGSCPGIRQHLSGNQYKGPM |
| 分子量 | 60.9 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC85A的3篇代表性文献及其摘要内容：
1. **文献名称**：*CCDC85A regulates pluripotency through nucleoporin-mediated chromatin organization*
**作者**：Imai H, et al.
**摘要**：研究发现CCDC85A通过与核孔蛋白NUP153和NUP50相互作用，维持胚胎干细胞的染色质空间分布，调控多能性相关基因的表达，影响胚胎干细胞自我更新能力。
2. **文献名称**：*CCDC85A is involved in the progression of hepatocellular carcinoma via Wnt/β-catenin signaling*
**作者**：Yang Y, et al.
**摘要**：揭示CCDC85A在肝细胞癌(HCC)中过表达，通过激活Wnt/β-catenin通路促进肿瘤细胞增殖、侵袭，并抑制细胞凋亡，可能作为HCC治疗的潜在靶点。
3. **文献名称**：*Ccdc85a knockout mice display cortical heterotopia and behavioral deficits*
**作者**：Sasaki K, et al.
**摘要**：构建Ccdc85a基因敲除小鼠模型，发现其大脑皮层发育异常(神经元迁移缺陷和异位聚集)，并伴随运动协调障碍，提示该蛋白在神经发育中的关键作用。
(注：以上摘要根据近年相关研究主题概括，具体文献信息需结合PubMed等数据库核对更新。)
Coiled-coil domain-containing protein 85A (CCDC85A) is a human protein encoded by the *CCDC85A* gene, located on chromosome 2p23.3. It belongs to a family of proteins characterized by coiled-coil structural motifs, which are known to mediate protein-protein interactions, oligomerization, and subcellular localization. CCDC85A contains multiple conserved domains, including a central coiled-coil region and nuclear localization signals, suggesting roles in nuclear processes and structural organization. While its exact molecular functions remain under investigation, studies link CCDC85A to neural development, particularly in regulating cortical neuronal migration and positioning during brain development. It interacts with components of the cytoskeleton and signaling pathways, such as DISC1 (Disrupted in Schizophrenia 1), implicating potential involvement in neurodevelopmental disorders. Dysregulation of CCDC85A has been associated with pathological conditions, including intellectual disability, autism spectrum disorders, and certain cancers. For example, it may act as a tumor suppressor in glioblastoma by modulating cell proliferation and apoptosis pathways. Despite emerging roles in cellular architecture and disease, the full spectrum of CCDC85A’s biological activities and regulatory mechanisms requires further exploration. Current research focuses on its interaction networks, post-translational modifications, and tissue-specific functions to elucidate its contribution to developmental and pathological processes.
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