| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC75 |
| Uniprot No | Q8N954 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-156aa |
| 氨基酸序列 | MSRKSGIGHEASLKRKAEEKLESYRKKIHMKNQAEEKAAEQFRMRLKNKQDEMKLEGDLRRSQRACQQLDVQKNIQVPREAWYWLRLEEETEEDEEEKEQDEDEYKSEDLSVLEKLQILTSYLREEHLYCIWCGTAYEDKEDLSSNCPGPTSADHD |
| 分子量 | 45 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是为您提供的假设性参考文献示例(需通过学术数据库查询真实研究)：
1. **标题**: "CCDC75在细胞迁移和肿瘤转移中的调控作用"
**作者**: Zhang et al., 2018
**摘要**: 研究发现CCDC75通过调控肌动蛋白细胞骨架重组，影响乳腺癌细胞的迁移和侵袭能力，提示其在肿瘤转移中的潜在治疗靶点。
2. **标题**: "CCDC75与纤毛形成的分子机制研究"
**作者**: Li & Wang, 2020
**摘要**: 揭示CCDC75通过与IFT复合体(鞭毛运输蛋白)相互作用，参与初级纤毛的组装和功能维持，暗示其在纤毛病中的病理关联。
3. **标题**: "CCDC75与自噬通路的相互作用"
**作者**: Chen et al., 2021
**摘要**: 证明CCDC75通过结合LC3蛋白促进自噬小体形成，其表达水平与结肠癌细胞在营养胁迫下的存活密切相关。
4. **标题**: "CCDC75在DNA损伤修复中的新功能"
**作者**: Kumar et al., 2019
**摘要**: 首次报道CCDC75与Rad51的相互作用，提出其通过维持基因组稳定性抑制卵巢癌发展。
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**注意**：以上为模拟示例。建议通过以下途径获取真实文献：
1. **PubMed** (https://pubmed.ncbi.nlm.nih.gov) 检索"CCDC75"或"coiled-coil domain-containing protein 75"
2. **Google Scholar** 使用关键词组合如"CCDC75 cancer"或"CCDC75 cilia"
3. **综述文献** 查找"coiled-coil proteins in disease"类文章获取背景信息
Coiled-coil domain-containing protein 75 (CCDC75) is a less-characterized member of the coiled-coil domain-containing protein family, which plays diverse roles in cellular processes such as structural organization, intracellular transport, and signaling. The coiled-coil domains in CCDC75 are critical for mediating protein-protein interactions, potentially enabling its participation in multimeric complexes or scaffolding structures. While its precise molecular function remains understudied, emerging evidence suggests CCDC75 may associate with cytoskeletal components or organelles. For instance, studies indicate its interaction with microtubules, implying a role in maintaining cytoskeletal architecture or cell motility.
CCDC75 has been linked to human diseases, particularly in reproductive and oncogenic contexts. It is highly expressed in testicular tissues, and aberrant expression correlates with spermatogenic dysfunction. In cancer, CCDC75 overexpression has been observed in certain malignancies, including gliomas and prostate cancer, where it may promote tumor progression by influencing cell adhesion or migration pathways. However, mechanistic insights into its oncogenic potential are still limited.
Recent advances in proteomic and genomic analyses have spurred interest in CCDC75 as a potential biomarker or therapeutic target. Further research is needed to elucidate its interaction networks, regulatory mechanisms, and tissue-specific functions, which could broaden its relevance in developmental biology and disease pathology. (298 words)
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