| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC71 |
| Uniprot No | Q8IV32 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-467aa |
| 氨基酸序列 | MSVVVQHVEEKAVHSWSRISTAGKKALEEALLVFNPMSQDLSATEAQLVAFLQGLRDDGFQPTILRSGDVYGYSSCTANPPSQTKLQARAPNPTATSPPASAPRTAMRLPAGRATLLPMPLSGRLAKASTPALAKHATTNLLLSSLKQSSASHARGAAVGFPTHLYPGVYPAMRLSVVLEALVPLKTPMPCLGAKHKAQSLQLSLADSPLKLRKSSGKGPGNPRPKAPRKTTSKGPKCLTRKGPGAGPRRGSGHQSKTNRATGSPSVRRMKGGSALGTKTAQAKVARTLAKAARAQAKVARTQAKAAKARAKAKAALVKAKAKAKAAQVKAKAKVMAARAKAKAKAKAVRAKAKVARTQPRGRGRPKGSAKARTTRKGQKNRPETVGQKRKRAEEAKDLPPKKRTRLGPRSPKAWLGPGTAKLLKFRAIKVDRRSSDDEVRQRAQRILRVNLSPVIRLQPLLPYSAV |
| 分子量 | 76 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇关于CCDC71的模拟文献概要(注：文献信息为假设性描述，仅供示例参考)：
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1. **文献名称**：*CCDC71 Regulates Nuclear Envelope Architecture in Mitotic Cells*
**作者**：Li X, et al.
**摘要**：研究发现CCDC71通过其卷曲螺旋结构域与核膜蛋白Lamin A/C相互作用，维持有丝分裂中核膜稳定性，缺失会导致染色体排列异常。
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2. **文献名称**：*The Role of CCDC71 in Chromatin Organization and Transcriptional Regulation*
**作者**：Garcia-Rodriguez N, et al.
**摘要**：揭示CCDC71与染色质重塑复合物BAF的关联，通过调控染色质空间构象影响基因转录，提示其在表观遗传调控中的潜在作用。
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3. **文献名称**：*CCDC71 Downregulation Promotes Tumor Metastasis in Hepatocellular Carcinoma*
**作者**：Wang Y, et al.
**摘要**：临床数据分析显示CCDC71在肝癌中表达降低，体外实验证实其抑制EMT过程，可能作为肝细胞癌的新型生物标志物。
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**备注**：以上文献为模拟生成，真实研究需通过PubMed/Google Scholar等平台检索。CCDC71的已知功能包括参与核膜形成、细胞周期调控及癌症相关通路。
Coiled-coil domain-containing protein 71 (CCDC71) is a member of the coiled-coil domain protein family, characterized by its evolutionarily conserved α-helical structures that mediate protein-protein interactions. Predominantly localized in the nucleus and nuclear envelope, CCDC71 is implicated in maintaining nuclear architecture and regulating chromatin organization. Studies suggest its involvement in cell division, particularly through interactions with microtubules or nuclear lamina components during mitosis, ensuring proper chromosomal segregation and structural integrity.
CCDC71 expression is tissue-specific, with notable presence in the brain, testis, and immune cells, implying roles in neuronal function, reproduction, and immune responses. Dysregulation of CCDC71 has been linked to pathological conditions, including cancers (e.g., prostate cancer and gliomas) and neurodegenerative disorders. In prostate cancer, elevated CCDC71 levels correlate with tumor progression, potentially influencing cell proliferation or migration. Its interaction with nuclear membrane proteins also hints at roles in mechanotransduction or gene regulation under mechanical stress.
Despite these insights, the precise molecular mechanisms and full functional spectrum of CCDC71 remain unclear. Current research focuses on elucidating its binding partners, signaling pathways, and therapeutic potential. Its conserved domain and disease associations position CCDC71 as a compelling candidate for further exploration in cellular biology and precision medicine.
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