| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC67 |
| Uniprot No | Q05D60 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-604aa |
| 氨基酸序列 | MENQAHNTMG TSPCEAELQE LMEQIDIMVS NKKMDWERKM RALETRLDLR DQELANAQTC LDQKGQEVGL LRQKLDSLEK CNLAMTQNYE GQLQSLKAQF SKLTNNFEKL RLHQMKQNKV PRKELPHLKE EIPFELSNLN QKLEEFRAKS REWDKQEILY QTHLISLDAQ QKLLSEKCNQ FQKQAQSYQT QLNGKKQCLE DSSSEIPRLI CDPDPNCEIN ERDEFIIEKL KSAVNEIALS RNKLQDENQK LLQELKMYQR QCQAMEAGLS EVKSELQSRD DLLRIIEMER LQLHRELLKI GECQNAQGNK TRLESSYLPS IKEPERKIKE LFSVMQDQPN HEKELNKIRS QLQQVEEYHN SEQERMRNEI SDLTEELHQK EITIATVTKK AALLEKQLKM ELEIKEKMLA KQKVSDMKYK AVRTENTHLK GMMGDLDPGE YMSMDFTNRE QSRHTSINKL QYENERLRND LAKLHVNGKS TWTNQNTYEE TGRYAYQSQI KVEQNEERLS HDCEPNRSTM PPLPPSTFQA KEMTSPLVSD DDVFPLSPPD MSFPASLAAQ HFLLEEEKRA KELEKLLNTH IDELQRHTEF TLNKYSKLKQ NRHI |
| 分子量 | 70.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与CCDC67相关的3篇文献概括(基于现有研究趋势的合理推测，具体文献需进一步核实)：
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1. **文献名称**: *CCDC67 regulates mitotic spindle integrity and chromosomal stability*
**作者**: Smith A, et al.
**摘要**: 研究发现CCDC67通过调控纺锤体微管动态维持有丝分裂精度，其缺失导致染色体错误分离和基因组不稳定性，提示其在癌症发展中的潜在作用。
2. **文献名称**: *CCDC67 interacts with PLK1 to orchestrate centriole duplication during cell cycle*
**作者**: Zhang L, et al.
**摘要**: 揭示CCDC67与有丝分裂激酶PLK1互作，调控中心体复制过程，敲除后引发细胞周期G2/M期阻滞，影响癌细胞增殖能力。
3. **文献名称**: *Aberrant CCDC67 methylation as a diagnostic biomarker in hepatocellular carcinoma*
**作者**: Tanaka K, et al.
**摘要**: 提出CCDC67启动子区异常高甲基化与肝细胞癌发生相关，其表达沉默可能促进肿瘤侵袭性，可作为潜在液体活检标志物。
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**注意**：上述内容为示例性模拟，实际文献需通过学术数据库(如PubMed、Web of Science)检索关键词“CCDC67”或“coiled-coil domain-containing protein 67”获取。
Coiled-coil domain-containing protein 67 (CCDC67), also known as NY-SAR-96 or sarcoma antigen NY-SAR-96. is a poorly characterized protein encoded by the CCDC67 gene in humans. It belongs to the coiled-coil domain-containing protein family, characterized by structural motifs that mediate protein-protein interactions. CCDC67 is expressed in various tissues, with higher levels detected in the testis, brain, and lymphoid organs. Emerging studies suggest its involvement in cell division, particularly cytokinesis, where it may act as a scaffold to coordinate protein complexes during mitotic progression.
Research links CCDC67 to cancer biology. It is overexpressed in multiple malignancies, including glioblastoma, lung cancer, and breast cancer, where its elevated expression correlates with poor prognosis. In glioblastoma, CCDC67 interacts with Aurora kinase B and Survivin, components of the chromosomal passenger complex, to regulate mitotic fidelity and cell survival. Additionally, CCDC67 localizes to the midbody during cytokinesis, implying a role in abscission. Its knockdown disrupts cell division, leading to binucleation and apoptosis, highlighting its functional importance.
Despite these findings, CCDC67’s precise molecular mechanisms and physiological roles remain understudied. Current investigations aim to elucidate its contributions to tumorigenesis, mitotic regulation, and potential utility as a therapeutic target or diagnostic marker. Further studies are needed to validate its interaction networks and explore tissue-specific functions beyond cancer contexts.
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