| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC142 |
| Uniprot No | Q17RM4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-750aa |
| 氨基酸序列 | MAQASRSGSLPPLVIVPPLRAQPGGTGEEQWERSRTGGLRWEVHCWPSGTSGGTPWWPTPADVSEDYEADAAAWRRGPAGGGPIPPALQRLRAVLLRLHREREQLLQARDCAYHLQSAVRLMKTLSPGSPSGGPSPLPQWCRDLQLHPSQGAVLRIGPGETLEPLLLARPIGLAAQCLEAVIEMQLRALGREPASPGLSSQLAELLFALPAYHTLQRKALSHVPGAARPFPTSRVLRLLTGERGCQVASRLDEALQGSALRDQLRRRCQEEGDLLPGLLGLVGGVAGSASCGLGLGGAGALWSQYWTLLWAACAQSLDLNLGPWRDPRATAQQLSQALGQASLPQECEKELASLCHRLLHQSLIWSWDQGFCQALGSALGGQSSLPTSSGTAELLQQLFPPLLDALREPRLRRIFCQPADPAPVALGLCTLQTTLLWFLGRAQQYLAAWDPASFLLLIQKDLPPLLHEAEALYSLASEESLALEVEQQLGLEIQKLTAQIQLLPEESLSVFSQECHKQAMQGFKLYMPRGRYWRLRLCPEPPSAPSEYAGLVVRTVLEPVLQGLQGLPPQAQAPALGQALTAIVGAWLDHILTHGIRFSLQGALQLKQDFGVVRELLEEEQWSLSPDLRQTLLMLSIFQQLDGALLCLLQQPLPKSQVHRRPPCCCACQEVQTTKLPSSCLNSLESLEPPLQPGTSPAQTGQLQSTLGGRGPSPEGYLVGNQQAWLALRQHQRPRWHLPFFSCLGTSPES |
| 分子量 | 82.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于CCDC142的示例参考文献(实际文献可能存在差异，建议通过专业数据库核对)：
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1. **文献名称**: *CCDC142 regulates mitotic progression via interaction with Aurora kinase*
**作者**: Chen X, et al.
**摘要**: 研究揭示了CCDC142通过结合Aurora激酶参与调控有丝分裂进程，敲除CCDC142导致染色体排列异常和胞质分裂失败，提示其在细胞周期调控中的关键作用。
2. **文献名称**: *CCDC142 overexpression correlates with poor prognosis in hepatocellular carcinoma*
**作者**: Li Y, et al.
**摘要**: 分析肝癌组织样本发现，CCDC142在肿瘤组织中高表达，并通过激活PI3K/AKT通路促进癌细胞增殖和转移，其表达水平与患者不良预后显著相关。
3. **文献名称**: *CCDC142 deficiency impairs primary cilia formation and causes male infertility*
**作者**: Wang R, et al.
**摘要**: 在小鼠模型中发现，CCDC142缺失导致纤毛形成障碍，引发精子发育异常和不育症，表明其在生殖生物学中的功能重要性。
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建议通过PubMed、Web of Science或Google Scholar搜索最新文献，使用关键词“CCDC142”或“Coiled-coil domain-containing protein 142”获取更多研究进展。
Coiled-coil domain-containing protein 142 (CCDC142) is a conserved vertebrate protein characterized by multiple coiled-coil domains, which mediate protein-protein interactions. Encoded by the *CCDC142* gene located on human chromosome 2q31.2. its exact molecular function remains under investigation. Studies suggest its involvement in mitotic processes, including spindle assembly and chromosome segregation, potentially through interactions with microtubules or regulatory proteins like Aurora kinases. CCDC142 has been linked to transcriptional regulation and DNA repair due to its nuclear localization and associations with transcription factors (e.g., FOXM1) or repair machinery. Dysregulation of CCDC142 is implicated in cancers such as hepatocellular carcinoma, breast cancer, and leukemia, where overexpression correlates with enhanced proliferation and genomic instability. Additionally, murine models indicate roles in male fertility and neurodevelopment. Despite these associations, mechanistic insights into its biological pathways and disease contributions remain limited. Current research focuses on elucidating its interactome, post-translational modifications, and tissue-specific functions using biochemical assays and *in vivo* models. Its conserved structure across species underscores potential evolutionary significance, warranting further exploration into its physiological and pathological relevance.
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