| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC132 |
| Uniprot No | Q96JG6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-327aa |
| 氨基酸序列 | MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTVCSDLITIHISLL |
| 分子量 | 63.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC132的示例性参考文献(内容为假设性概括，仅供参考)：
1. **文献名称**: "CCDC132 regulates spermatogenesis through structural interactions in the sperm tail"
**作者**: Li X, et al.
**摘要**: 研究发现CCDC132在哺乳动物睾丸中高表达，参与精子尾部结构的形成。通过基因敲除模型发现，CCDC132缺失导致精子运动能力缺陷，揭示其在雄性生殖中的关键作用。
2. **文献名称**: "CCDC132 interacts with VCP in ALS-linked protein aggregation pathways"
**作者**: Zhang Y, et al.
**摘要**: 该研究通过蛋白质组学分析，发现CCDC132与Valosin-containing protein (VCP)相互作用，可能在肌萎缩侧索硬化症(ALS)中调控异常蛋白的清除，其突变或异常表达导致神经元内蛋白聚集。
3. **文献名称**: "Genomic instability induced by CCDC132 depletion in hepatocellular carcinoma"
**作者**: Wang L, et al.
**摘要**: 本文证明CCDC132缺失与肝癌患者预后不良相关。体外实验显示，CCDC132通过维持染色体稳定性抑制肿瘤生长，其功能失调可能导致基因组异常和癌症进展。
4. **文献名称**: "The role of CCDC132 in mitotic chromosome segregation"
**作者**: Tanaka K, et al.
**摘要**: 研究发现CCDC132在有丝分裂中参与姐妹染色体的分离，敲低后导致染色体错配和细胞周期停滞，提示其在细胞分裂中的保守功能及其与遗传疾病潜在关联。
**注意**：上述文献为示例性描述，实际研究需通过PubMed、Web of Science等平台检索最新论文。
Coiled-coil domain-containing protein 132 (CCDC132) is a relatively understudied protein encoded by the *CCDC132* gene in humans, located on chromosome 7q31.32. Structurally, it is characterized by multiple coiled-coil domains, which mediate protein-protein interactions, suggesting a role in scaffolding or assembling multi-protein complexes. The protein is ubiquitously expressed across tissues, with higher levels observed in the brain, testis, and thyroid. While its precise biological functions remain unclear, emerging studies link CCDC132 to cellular processes such as intracellular trafficking, microtubule dynamics, and possibly mitosis. Proteomic analyses have identified interactions with components of the dynein-dynactin motor complex and microtubule-associated proteins, implicating it in organelle transport or cytoskeletal organization. Dysregulation of CCDC132 has been tentatively associated with cancers, including prostate and thyroid malignancies, though mechanistic insights are limited. Additionally, rare genetic variants in *CCDC132* have been reported in neurological disorders, hinting at potential neurodevelopmental roles. Current research gaps include a lack of *in vivo* functional validation, unclear signaling pathways, and undefined connections to disease pathogenesis. Further studies are needed to elucidate its molecular mechanisms, post-translational modifications, and therapeutic relevance.
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