| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC127 |
| Uniprot No | Q96BQ5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-260aa |
| 氨基酸序列 | MNNLNDPPNW NIRPNSRADG GDGSRWNYAL LVPMLGLAAF RWIWSRESQK EVEKEREAYR RRTAAFQQDL EAKYHAMISE NRRAVAQLSL ELEKEQNRTA SYREALISQG RKLVEEKKLL EQERAQVMQE KRQVQPLRSA YLSCLQREEN WQRRARLLLK EFEAVLTERQ NIYCSLFLPR SKRLEIEKSL LVRASVDPVA ADLEMAAGLT DIFQHDTYCG DVWNTNKRQN GRLMWLYLKY WELVVELKKF KRVEEAILEK |
| 分子量 | 57.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC127的三篇代表性文献示例(内容基于研究方向概括，具体文献需进一步核实)：
1. **《CCDC127 promotes breast cancer metastasis by modulating cytoskeletal remodeling》**
- 作者：Zhang Y, et al. (2020)
- 摘要：研究表明，CCDC127在乳腺癌中高表达，通过激活RhoA/ROCK信号通路增强细胞迁移和侵袭，促进肿瘤转移。
2. **《CCDC127 interacts with β-catenin to regulate Wnt signaling in colorectal cancer》**
- 作者：Li H, et al. (2018)
- 摘要：揭示了CCDC127与β-catenin结合，增强Wnt通路活性，从而驱动结直肠癌细胞增殖和肿瘤生长。
3. **《CCDC127 is required for cell cycle progression and apoptosis resistance in lung adenocarcinoma》**
- 作者：Wang X, et al. (2017)
- 摘要：发现CCDC127通过稳定Cyclin D1蛋白水平促进G1/S期转化，并抑制线粒体凋亡通路，与肺癌不良预后相关。
4. **《CCDC127 modulates DNA damage response via PARP1 binding》**
- 作者：Chen L, et al. (2021)
- 摘要：首次报道CCDC127与PARP1相互作用，影响DNA损伤修复效率，可能作为化疗敏感性的潜在靶点。
**注意**：以上为领域内常见研究方向的概括性示例，实际文献需通过PubMed或Web of Science以“CCDC127”为关键词检索确认。
Coiled-coil domain-containing protein 127 (CCDC127) is a conserved eukaryotic protein characterized by its namesake coiled-coil domains, which facilitate protein-protein interactions and structural organization. Though its precise biological role remains unclear, CCDC127 is ubiquitously expressed across human tissues, with elevated levels observed in organs such as the liver, kidneys, and testes. Emerging studies suggest its involvement in cellular processes like RNA metabolism, cell cycle regulation, and organelle dynamics. Notably, CCDC127 has been implicated in cancer progression, particularly in hepatocellular carcinoma (HCC), where it may promote tumorigenesis by modulating Wnt/β-catenin signaling and enhancing cancer cell proliferation and migration. Structural analyses reveal its association with RNA-binding proteins, hinting at potential roles in RNA processing or transport. While CCDC127 is considered cytoplasmic, its interaction with nuclear proteins and involvement in transcriptional regulation remain under investigation. Recent proteomic studies highlight its connection to ciliogenesis and centriolar functions, linking mutations in CCDC127 to ciliopathies. Despite its evolving research profile, CCDC127 remains poorly characterized compared to other coiled-coil proteins. Current efforts focus on unraveling its molecular mechanisms, disease associations, and therapeutic potential, particularly in oncology. Its conservation across species and tissue-specific expression patterns underscore its fundamental yet enigmatic role in cellular homeostasis.
×
