| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CACNG7 |
| Uniprot No | P62955 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-275aa |
| 氨基酸序列 | MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQNQTTEVKMALHAGLWRVCFFAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATPFPMVSLFLVFTAFVISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNRPSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC |
| 分子量 | 57.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CACNG7蛋白的假设参考文献示例(实际文献需通过学术数据库查询)：
1. **"CACNG7 regulates synaptic plasticity in hippocampal neurons"**
*作者：Johnson et al. (2015)*
**摘要**：研究揭示了CACNG7(γ7亚基)通过调控AMPA受体运输参与海马神经元突触可塑性的机制，敲低CACNG7导致长时程增强(LTP)受损。
2. **"Altered expression of CACNG7 in Alzheimer's disease brain tissues"**
*作者：Smith et al. (2020)*
**摘要**：通过分析阿尔茨海默病患者脑组织样本，发现CACNG7蛋白表达显著下调，可能与钙信号失调及神经元退行性病变相关。
3. **"CACNG7 modulates T-type calcium channel activity in neuroendocrine cells"**
*作者：Chen et al. (2022)*
**摘要**：利用电生理和蛋白质互作实验，证实CACNG7与Cav3.2 T型钙通道结合，调控其门控动力学及神经内分泌细胞的激素分泌功能。
4. **"CACNG7 as a potential biomarker in lung adenocarcinoma"**
*作者：Müller et al. (2018)*
**摘要**：基于TCGA数据分析，发现肺癌组织中CACNG7基因甲基化水平升高且与患者生存率负相关，提示其可能作为治疗靶点或预后标志物。
注：以上内容为模拟简化示例，具体文献需通过PubMed/Google Scholar等平台以"CACNG7 protein"、"gamma-7 calcium channel subunit"等关键词检索。
CACNG7. a member of the voltage-gated calcium channel γ subunit family, is a transmembrane protein primarily involved in regulating calcium channel activity. These γ subunits, distinct from Cav channel pore-forming subunits (α1), act as auxiliary components that modulate channel trafficking, kinetics, and membrane localization. CACNG7. also termed γ-7. is encoded by the *CACNG7* gene and shares structural homology with stargazin (γ-2), featuring four transmembrane domains and a cytosolic C-terminus. It forms hetero-oligomeric complexes with other γ subunits or interacts with α1 subunits of Cav channels (e.g., Cav2.1. Cav2.2) to influence calcium influx, critical for neuronal excitability and signaling.
Expressed predominantly in the brain, particularly in regions like the cortex, hippocampus, and cerebellum, CACNG7 is implicated in synaptic plasticity and neurotransmitter release. Studies suggest its role in neurological disorders, including epilepsy, neuropathic pain, and psychiatric conditions, as dysregulated calcium signaling underlies these pathologies. Knockdown or mutations in *CACNG7* alter channel surface expression and electrophysiological properties, highlighting its regulatory importance. Recombinant CACNG7 protein, often produced in mammalian systems for post-translational fidelity, serves as a tool to study Cav channel modulation mechanisms and screen therapeutic agents targeting calcium-related diseases. Its interplay with AMPA receptors further links calcium homeostasis to synaptic strength, emphasizing its dual regulatory functions.
×
