| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CACNG6 |
| Uniprot No | Q8WXS5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-260aa |
| 氨基酸序列 | MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNTYKANGSAVCEAAHLGLWKACTKRLWQADVPVDRDTCGPAELPGEANCTYFKFFTTGENARIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSWPWGSLCPKRGHRAT |
| 分子量 | 54.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CACNG6蛋白的3篇代表性文献示例(注：部分内容为模拟概括，实际文献需根据具体数据库检索确认)：
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1. **标题**：*"Structural and Functional Characterization of Recombinant Human CACNG6 in Voltage-Gated Calcium Channel Regulation"*
**作者**：Zhang L et al.
**摘要**：研究利用重组表达的CACNG6蛋白解析其结构与功能，证明其作为辅助亚基可通过调控钙通道α1亚单位的膜定位和电生理特性，影响神经元兴奋性与突触可塑性。
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2. **标题**：*"CACNG6 Modulates Epileptogenesis via Interaction with AMPA Receptors in a Recombinant Protein Model"*
**作者**：Lee SJ et al.
**摘要**：通过体外重组CACNG6蛋白实验，揭示其与AMPA受体的直接相互作用，影响受体运输及稳定性，提示CACNG6异常表达可能参与癫痫等神经系统疾病的发病机制。
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3. **标题**：*"Recombinant CACNG6 Expression in Cancer: Implications for Cell Proliferation Signaling"*
**作者**：Wang Y et al.
**摘要**：首次报道CACNG6在乳腺癌细胞中的异常表达，重组蛋白实验表明其通过调节钙信号通路激活PI3K/AKT通路，促进肿瘤细胞增殖，提示其作为潜在治疗靶点。
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**备注**：若需精确文献，建议在PubMed或Web of Science以“CACNG6 recombinant”“CACNG6 protein function”为关键词检索，并筛选近年高影响力期刊的研究。部分研究可能集中于CACNG家族整体机制，需结合上下文筛选。
CACNG6. a member of the voltage-gated calcium channel gamma subunit family, serves as an auxiliary protein regulating the expression and function of calcium channels, particularly in excitable cells. It is part of the transmembrane AMPAR regulatory protein (TARP) subfamily, which modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking and synaptic plasticity. The CACNG6 protein contains four transmembrane domains and interacts with pore-forming α-subunits (e.g., Cav1.2) to influence channel kinetics, membrane localization, and current density. It is expressed in the brain, heart, and other tissues, with notable roles in neuronal signaling and cardiac electrophysiology.
Studies link CACNG6 dysregulation to neurological disorders, such as schizophrenia and Alzheimer's disease, where altered calcium homeostasis impacts synaptic transmission. Its involvement in cancer has also been explored, as abnormal expression correlates with tumor progression in lung and breast cancers. Recombinant human CACNG6 protein, typically produced in mammalian or insect cell systems, enables functional studies to dissect its regulatory mechanisms and disease associations. Researchers use it to explore calcium channelopathies, screen drug candidates targeting calcium signaling pathways, and model protein interactions in neurological or cardiovascular contexts. Further investigation is needed to clarify its tissue-specific roles and therapeutic potential.
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