| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C9orf98 |
| Uniprot No | Q96MA6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-479aa |
| 氨基酸序列 | MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP |
| 分子量 | 81.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下列举了几篇关于 **C9orf72** 蛋白(注：用户提及的“C9orf98”可能为笔误，因C9orf72是神经退行性疾病研究热点基因)的关键参考文献，简要内容如下：
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1. **文献名称**：*Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS*
**作者**：DeJesus-Hernandez et al. (2011)
**摘要**：首次发现C9orf72基因非编码区的GGGGCC六核苷酸重复扩增是家族性肌萎缩侧索硬化症(ALS)和额颞叶痴呆(FTD)的重要病因，提示其通过毒性RNA或蛋白聚集致病。
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2. **文献名称**：*A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD*
**作者**：Renton et al. (2011)
**摘要**：独立验证C9orf72重复扩增突变在ALS和FTD患者中的高频存在，表明该突变是欧洲人群ALS/FTD最常见的遗传因素，推动了后续致病机制研究。
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3. **文献名称**：*The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in ALS/FTD*
**作者**：Mori et al. (2013)
**摘要**：提出C9orf72重复扩增可通过非ATG依赖的翻译机制产生多种毒性二肽重复蛋白(如poly-GA、poly-PR)，这些蛋白在患者神经元中形成包涵体，干扰细胞功能。
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4. **文献名称**：*Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS*
**作者**：Ash et al. (2013)
**摘要**：证实C9orf72重复序列可通过非经典翻译生成不溶性多肽，并阐明了其在不同脑区累积与神经元退化的关联，为治疗靶点开发提供依据。
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**备注**：若用户确需“C9orf98”蛋白相关文献，目前可查的公开研究极少，建议核对基因名称或提供更多背景信息。
C9orf98. also known as chromosome 9 open reading frame 98. is a human protein-coding gene whose biological functions remain largely uncharacterized. The gene is located on the short arm of chromosome 9 (9p13.3) and encodes a protein of approximately 25-30 kDa. Recombinant C9orf98 protein is typically produced via heterologous expression systems (e.g., E. coli or mammalian cells) for structural and functional studies. Bioinformatics analyses suggest it contains putative coiled-coil domains and potential phosphorylation sites, hinting at roles in protein-protein interactions or signaling pathways. However, experimental validation remains limited.
Emerging studies associate C9orf98 with cellular processes such as cell cycle regulation and DNA damage response, though mechanistic insights are sparse. Some reports propose links to cancer progression, with differential expression observed in tumor tissues, though findings are inconsistent across cancer types. Notably, its genomic proximity to the C9orf72 locus (linked to ALS/FTD neurodegeneration) has spurred interest in potential neurological connections, but direct evidence is lacking. Research efforts focus on identifying interaction partners and post-translational modifications to elucidate its physiological role. Current challenges include resolving conflicting functional predictions and establishing standardized detection tools due to antibody specificity issues. Further investigation is required to clarify its contribution to human health and disease.
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