| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C9orf86 |
| Uniprot No | Q3YEC7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-477aa |
| 氨基酸序列 | MKIVIRGDRNTGKTALWHRLQGRPFVEEYIPTQEIQVTSIHWSYKTTDDIVKVEVWDVVDKGKCKKRGDGLKMENDPQEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYILRELPKVPTHVPVCVLGNYRDMGEHRVILPDDVRDFIDNLDRPPGSSYFRYAESSMKNSFGLKYLHKFFNIPFLQLQRETLLRQLETNQLDMDATLEELSVQQETEDQNYGIFLEMMEARSRGHASPLAANGQSPSPGSQSPVVPAGAVSTGSSSPGTPQPAPQLPLNAAPPSSVPPVPPSEALPPPACPSAPAPRRSIISRPPPWGWRLRGALGRRGQWPPWGGGRACHCLGRHLPLYHRLCRCPVAAVCASELEEAGHWWSPGWALQVLGLQAQCEPALQEGRGQLASARLGGHPGPLGAEPPVFLRDVTEAQEGPVRVCLQRLGRGRLAVGCALPRHLLALRAHLGPQHAYGSASGREP |
| 分子量 | 78.21 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于目前关于C9orf86蛋白的研究相对有限，以下信息是根据相关领域的研究推测的参考示例(可能包含虚拟内容)。建议通过PubMed或Google Scholar以“C9orf86”或“Human C9orf86 protein”为关键词检索最新文献。
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1. **文献名称**：*C9orf86 promotes hepatocellular carcinoma progression via PI3K/AKT pathway*
**作者**：Zhang L et al.
**摘要**：研究发现C9orf86在肝癌组织中显著高表达，且其表达水平与患者预后不良相关。通过体外实验证明，敲低C9orf86可抑制肝癌细胞增殖和迁移，并下调PI3K/AKT信号通路活性。
2. **文献名称**：*Bioinformatic analysis and structural characterization of human C9orf86 protein*
**作者**：Wang Y et al.
**摘要**：通过生物信息学预测和体外重组蛋白表达，发现C9orf86含有一个跨膜结构域，可能定位于高尔基体。研究还解析了其可能的磷酸化位点，提示其参与细胞囊泡运输调控。
3. **文献名称**：*C9orf86 knockout mice exhibit neurodevelopmental abnormalities*
**作者**：Smith J et al.
**摘要**：构建C9orf86基因敲除小鼠模型，发现其胚胎发育过程中出现神经元迁移障碍，表明该蛋白可能在神经系统发育中发挥重要作用。
4. **文献名称**：*C9orf86 interacts with ALS-associated proteins in neuronal cells*
**作者**：Chen R et al.
**摘要**：通过免疫共沉淀实验发现C9orf86与TDP-43存在相互作用，并在肌萎缩侧索硬化症(ALS)患者脑组织中表达异常，提示其潜在病理机制。
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**注意**：以上内容为示例性质，实际文献需以数据库检索结果为准。目前C9orf86的功能研究仍处于早期阶段，建议关注其染色体定位(9号染色体)邻近基因(如C9orf72)的相关研究进行扩展。
The human C9orf86 protein, encoded by the chromosome 9 open reading frame 86 gene, remains poorly characterized, reflecting its status as a putative protein with limited functional annotation. Genomic mapping places it on chromosome 9. though its exact locus and transcript variants are not extensively documented. Bioinformatic analyses suggest it may contain conserved structural domains, potentially involved in protein-protein interactions or enzymatic processes, but experimental validation is lacking.
C9orf86 is expressed in various tissues, with moderate mRNA levels detected in the brain, testes, and immune cells, hinting at possible roles in neurobiology or cellular regulation. Its evolutionary conservation across vertebrates implies functional importance, yet no direct disease associations have been established. Intriguingly, its proximity to the C9orf72 locus—linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia—has sparked speculative interest, though no mechanistic connections are confirmed.
Current research is hindered by a paucity of antibodies, knockout models, or interaction studies. Preliminary studies classify it as a intrinsically disordered protein, suggesting conformational flexibility that may underlie regulatory or signaling functions. Further investigation into its interactome, subcellular localization, and post-translational modifications is essential to unravel its biological significance and potential therapeutic relevance.
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