关键信息
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基因名
ACCN5
- 应用
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别名
amiloride sensitive cation channel 5. intestinal、Amiloride sensitive sodium channel
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal.
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NY37
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表达区间
1-505aa
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氨基酸序列
MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
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分子量
82.5 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ACCN5, also known as the acid-sensing ion channel 5, is a member of the transient receptor potential (TRP) channel family and is primarily involved in sensing environmental changes, particularly in response to acidic pH. This channel has gained attention in recent years due to its potential role in various physiological and pathophysiological processes, including pain sensation, neurotransmission, and cellular signaling. Understanding ACCN5's structure and function is crucial for elucidating its mechanisms in these processes, which may contribute to the development of new therapeutic strategies for managing pain and other disorders. The study of recombinant ACCN5 protein is essential for characterizing its biophysical properties, ion permeability, and interaction with other cellular components. By producing and analyzing ACCN5 in a controlled laboratory setting, researchers can decipher its functional roles and potentially identify small molecules or drugs that selectively modulate its activity. Additionally, recombinant ACCN5 can be used to investigate its involvement in diseases such as inflammation and neurodegeneration, paving the way for innovative treatments that target this channel. Therefore, research on ACCN5 recombinant protein is a promising direction in both basic science and applied medical research, with implications for understanding pain mechanisms and developing new interventions for related conditions.
