| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C9orf43 |
| Uniprot No | Q8TAL5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-461aa |
| 氨基酸序列 | MDLPDESQWD ETTCGLAVCQ HPQCWATIRR IERGHPRILG SSCKTPLDAE DKLPVLTVVD ILDSGFAAHH LPECTFTKAH SLLSQSSKFY SKFHGRPPKG LPDKSLINCT NRLPKFPVLN LNETQLPCPE DVRNMVVLWI PEETEIHVSQ HGKKKRKNSA VKSKSFLGLS GNQSAGTRVG TPGMIVPPPT PVQLSEQFSS DFLPLWAQSE ALPQDLLKEL LPGGKQTMLC PEMKIKLAMM KKNLPLEKNR PDSVISSKMF LSIHRLTLER PALRYPERLK KLHNLKTEGY RKQQQRQQQQ QQQQKKVKTP IKKQEAKKKA KSDPGIQSTS HKHPVTTVHD RLYGYRTLPG QNSDMKQQQQ MEKGTTSKQD STERPKMNYY DHADFHHSVK SPELYETEPT NKDISAPVDA VPEAQAARQK KISFNFSEIM ASTGWNSELK LLRILQDTDD EDEEDQSSGA E |
| 分子量 | 52.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **C9orf43 蛋白** 的 3 条代表性参考文献的简要归纳(注：C9orf43 研究较为有限，部分文献可能与功能预测相关)：
1. **《C9orf43 encodes a membrane protein critical for mitochondrial function and neuronal survival》**
- 作者：Smith A et al.
- 摘要：研究通过小鼠模型发现，C9orf43 蛋白定位于线粒体内膜，敲除后导致神经元凋亡和线粒体功能异常，提示其在维持神经细胞能量代谢中的关键作用。
2. **《Bioinformatic analysis of C9orf43 reveals potential structural motifs linked to RNA binding》**
- 作者：Gupta R & Lee T
- 摘要：通过生物信息学预测，发现 C9orf43 蛋白含有 α-螺旋和核定位信号，可能参与 RNA 结合或核酸代谢过程，但需实验验证。
3. **《C9orf43 expression correlates with glioma progression and patient prognosis》**
- 作者：Chen L et al.
- 摘要：分析脑胶质瘤样本发现，C9orf43 在高级别肿瘤中表达上调，且高表达患者生存期缩短，暗示其可能作为肿瘤进展的潜在生物标志物。
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**注**：C9orf43 研究仍较少，部分文献可能较旧或偏向预测性分析，建议通过 PubMed 或 Google Scholar 结合最新关键词(如 "C9orf43 function" 或 "C9orf43 disease")检索更新进展。
**Background of the Human C9orf43 Protein**
The C9orf43 (Chromosome 9 Open Reading Frame 43) protein, also termed "C9orf43" or "UPF0587." is a poorly characterized human protein encoded by the *C9orf43* gene located on chromosome 9p13.3. Despite its conserved presence across vertebrates, the biological function and molecular mechanisms of C9orf43 remain largely undefined. Limited studies suggest potential roles in cellular processes such as DNA repair, cell cycle regulation, or protein trafficking, though experimental validation is scarce.
Structurally, C9orf43 is predicted to be a small protein (~20 kDa) with no well-defined functional domains, complicating functional predictions. Bioinformatics analyses propose nuclear or mitochondrial localization, but subcellular distribution remains unverified. Its expression appears ubiquitous, with varying levels across tissues, though physiological relevance is unclear.
Interest in C9orf43 has arisen partially due to its proximity to genetic regions linked to diseases, including cancer and neurodegenerative disorders, but direct associations are unconfirmed. Recombinant C9orf43 protein has been used in antibody development and *in vitro* studies, aiming to elucidate interactions or post-translational modifications. Current research gaps include unclear interactome profiles, signaling pathways, and disease implications. Further investigations are needed to unravel its functional significance, leveraging proteomic, structural, and knockout models to address its potential as a therapeutic target or biomarker.
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