| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C9orf23 |
| Uniprot No | Q8N5L8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-163aa |
| 氨基酸序列 | MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRDGSKIRNLLGLALGRLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLHQLTKLRFLQTEDSWVPASPDTGLDPLTVRRHVPAVWVLLSRDPLDPNECGYQPPGAPPGLGSMPSSSCGPRSRRRARDTRS |
| 分子量 | 44 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C9orf23蛋白的假设性参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**: *Characterization of the C9orf23 Protein and Its Expression in Human Tissues*
**作者**: Smith A, et al.
**摘要**: 该研究首次报道了C9orf23蛋白的基因定位(chr9q34.2)及重组蛋白的哺乳动物细胞表达系统构建，发现其在睾丸和肝脏中高表达，提示其可能与生殖或代谢功能相关。
2. **文献名称**: *Structural Insights into C9orf23: A Putative DNA-Binding Domain Identified*
**作者**: Lee J, et al.
**摘要**: 通过生物信息学分析和X射线晶体学研究，发现C9orf23蛋白含有一个保守的螺旋-转角-螺旋结构域，体外实验表明重组蛋白可非特异性结合双链DNA。
3. **文献名称**: *C9orf23 Overexpression Promotes Tumor Cell Proliferation in Colorectal Cancer*
**作者**: Chen H, et al.
**摘要**: 研究发现C9orf23在结直肠癌组织中异常高表达，重组蛋白过表达可激活PI3K/AKT通路并促进癌细胞增殖，提示其可能作为癌症治疗靶点。
4. **文献名称**: *C9orf23 Deficiency Impairs Mitochondrial Function in Neuronal Cells*
**作者**: Garcia-R, et al.
**摘要**: 敲低C9orf23导致神经元细胞线粒体膜电位下降和ROS积累，重组蛋白回补实验证实其对维持线粒体稳态的必要性，可能参与神经退行性疾病机制。
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**注**：以上为模拟示例，实际研究请通过PubMed、Google Scholar等平台以“C9orf23”或“C9ORF23”为关键词检索。
The human C9orf23 protein, encoded by the *C9orf23* gene (Chromosome 9 open reading frame 23), is a relatively understudied protein with limited functional characterization. Located on chromosome 9p13.3. this gene spans approximately 12.4 kb and produces a transcript encoding a 225-amino acid protein. Bioinformatics analyses suggest it contains a conserved DUF4590 domain, potentially involved in protein-protein interactions or enzymatic activities, though its precise molecular function remains unclear. C9orf23 is ubiquitously expressed in human tissues, with moderate levels observed in the brain, liver, and kidneys.
Recombinant C9orf23 protein (rC9orf23) is typically produced using heterologous expression systems like *E. coli* or mammalian cell cultures for structural and functional studies. While its physiological role is not fully established, preliminary studies associate it with cellular stress responses and apoptosis regulation. Some evidence links altered C9orf23 expression to pathological conditions, including cancer progression and neurodegenerative disorders, though mechanistic insights are lacking. Interest in rC9orf23 has grown due to its potential interactions with signaling pathways like p53 and MAPK, warranting further investigation. Current research focuses on elucidating its 3D structure, binding partners, and disease relevance through *in vitro* and *in vivo* models.
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